Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 24, Number 4—April 2018
Research

Artemisinin-Resistant Plasmodium falciparum with High Survival Rates, Uganda, 2014–2016

Mie Ikeda, Megumi Kaneko, Shin-Ichiro Tachibana, Betty Balikagala, Miki Sakurai-Yatsushiro, Shouki Yatsushiro, Nobuyuki Takahashi, Masato Yamauchi, Makoto Sekihara, Muneaki Hashimoto1, Osbert T. Katuro2, Alex Olia3, Paul S. Obwoya, Mary A. Auma, Denis A. Anywar, Emmanuel I. Odongo-Aginya, Joseph Okello-Onen4, Makoto Hirai, Jun Ohashi, Nirianne M.Q. Palacpac, Masatoshi Kataoka, Takafumi Tsuboi, Eisaku Kimura, Toshihiro Horii, and Toshihiro MitaComments to Author 
Author affiliations: Juntendo University School of Medicine, Tokyo, Japan (M. Ikeda, M. Kaneko, S.-I. Tachibana, M. Yamauchi, M. Sekihara, M. Hashimoto, M. Hirai, T. Mita); Ehime University, Matsuyama, Japan (B. Balikagala, T. Tsuboi); Tokyo Women’s Medical University, Tokyo (M. Sakurai-Yatsushiro, N. Takahashi); National Institute of Advanced Industrial Science and Technology, Kagawa, Japan (S. Yatsushiro, M. Kataoka); Med Biotech Laboratories, Kampala, Uganda (O.T. Katuro); Gulu University, Gulu, Uganda (A. Olia, D.A. Anywar, E.I. Odongo-Aginya, J. Okello-Onen); St. Mary’s Hospital Lacor, Gulu (P.S. Obwoya, M.A. Auma); The University of Tokyo, Tokyo (J. Ohashi); Osaka University, Osaka, Japan (N.M.Q. Palacpac, E. Kimura, T. Horii)

Main Article

Figure 3

Distribution of IC50 of Plasmodium falciparum values by dihydroartemisinin in conventional ex vivo drug susceptibility assay. IC50 values to dihydroartemisinin in conventional ex vivo drug susceptibility assay are plotted. Geometric mean IC50 values in isolates with survival rates of 0, >0 to <10%, and >10% (high RSA survival) were 3.0 nmol/L (n = 74), 1.9 nmol/L (n = 14), and 3.3 nmol/L (n = 3), respectively. In the conventional ex vivo drug susceptibility assay, replication of parasit

Figure 3. Distribution of IC50 of Plasmodium falciparum values by dihydroartemisinin in conventional ex vivo drug susceptibility assay. IC50 values to dihydroartemisinin in conventional ex vivo drug susceptibility assay are plotted. Geometric mean IC50 values in isolates with survival rates of 0, >0 to <10%, and >10% (high RSA survival) were 3.0 nmol/L (n = 74), 1.9 nmol/L (n = 14), and 3.3 nmol/L (n = 3), respectively. In the conventional ex vivo drug susceptibility assay, replication of parasites was monitored after continuous exposure to dihydroartemisinin for 72 h. Dashed line indicates geometric mean IC50 value of all isolates (2.25 nmol/L). IC50, concentration needed to inhibit 50% growth; RSA, ring-stage survival assay.

Main Article

1Current affiliation: National Institute of Advanced Industrial Science and Technology, Kagawa, Japan.

2Current affiliation: Mildmay Uganda-KAMPALA, Kampala, Uganda.

3Current affiliation: Gunma University, Gunma, Japan.

4Deceased.

Page created: March 16, 2018
Page updated: March 16, 2018
Page reviewed: March 16, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external