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Volume 24, Number 4—April 2018
Research

Phenotypic and Genotypic Characterization of Enterobacteriaceae Producing Oxacillinase-48–Like Carbapenemases, United States

Joseph D. LutgringComments to Author , Wenming Zhu, Tom J.B. de Man, Johannetsy J. Avillan, Karen F. Anderson, David R. Lonsway, Lori A. Rowe, Dhwani Batra, J. Kamile Rasheed, and Brandi M. Limbago
Author affiliations: Emory University School of Medicine, Atlanta, Georgia, USA (J.D. Lutgring); Centers for Disease Control and Prevention, Atlanta (J.D. Lutgring, W. Zhu, T.J.B. de Man, J.J. Avillan, K.F. Anderson, D.R. Lonsway, L.A. Rowe, D. Batra, J.K. Rasheed, B.M. Limbago)

Main Article

Figure 2

Sequence structure of 2 β-lactamase OXA-48 (blaOXA-48) plasmids tested during phenotypic and genotypic characterization of Enterobacteriaceae producing OXA-48–like carbapenemases, United States. Top plasmid is from isolate 23 in this study (pIncL_M_DHQP1400954) (72,093 bp), and bottom plasmid is from Chen et al. (44) (GenBank accession no. KP025948). Arrows indicate direction of transcription. Red arrows indicate other genes. Gray area indicates regions of homology, white lines indicate nonhomol

Figure 2. Sequence structure of 2 β-lactamase OXA-48 (blaOXA-48) plasmids tested during phenotypic and genotypic characterization of Enterobacteriaceae producing OXA-48–like carbapenemases, United States. Top plasmid is from isolate 23 in this study (pIncL_M_DHQP1400954) (72,093 bp), and bottom plasmid is from Chen et al. (44) (GenBank accession no. KP025948). Arrows indicate direction of transcription. Red arrows indicate other genes. Gray area indicates regions of homology, white lines indicate nonhomologous regions, and gray lines indicate inversions. aph, aminoglycoside; OXA, oxacillinase; repA, IncL/M type replicase; str, streptomycin.

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