Volume 24, Number 4—April 2018
Research
Phenotypic and Genotypic Characterization of Enterobacteriaceae Producing Oxacillinase-48–Like Carbapenemases, United States
Joseph D. Lutgring
, Wenming Zhu, Tom J.B. de Man, Johannetsy J. Avillan, Karen F. Anderson, David R. Lonsway, Lori A. Rowe, Dhwani Batra, J. Kamile Rasheed, and Brandi M. Limbago
, Wenming Zhu, Tom J.B. de Man, Johannetsy J. Avillan, Karen F. Anderson, David R. Lonsway, Lori A. Rowe, Dhwani Batra, J. Kamile Rasheed, and Brandi M. Limbago
Table 3
MIC results for Enterobacteriaceae harboring β-lactamase oxacillinase-48–like carbapenemases, United States*
| Isolate no. | Species | Drug, MIC, μg/mL |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ETP | MEM | IMP | DOR | TZP | CRO | CAZ | FEP | CIP | COL | TIG | AMK | ||
| 1 | Klebsiella pneumoniae | >4 | 4 | 4 | 4 | >128 | >32 | >32 | >32 | >8 | <0.25 | 2 | 4 |
| 2 | K. pneumoniae | >8 | 4 | 2 | 4 | >128 | >32 | >128 | >32 | >8 | <0.5 | 2 | >64 |
| 3 | K. pneumoniae | >8 | 4 | 2 | 4 | >128 | >32 | >128 | >32 | >8 | 1 | 1 | >64 |
| 4 | K. pneumoniae | 8 | 2 | 4 | 2 | >128 | >32 | >128 | >32 | >8 | 0.5 | <0.5 | >64 |
| 5 | K. pneumoniae | 8 | 2 | 2 | 2 | >128 | >32 | >128 | >32 | >8 | 0.5 | <0.5 | >64 |
| 6 | K. ozaenae | >8 | 4 | 4 | 4 | >128 | >32 | >128 | >32 | >8 | 0.5 | 1 | >64 |
| 7 | K. pneumoniae | >8 | >8 | 4 | >8 | >128 | >32 | >128 | >32 | >8 | 1 | 4 | 32 |
| 8 | K. pneumoniae | >8 | 8 | 4 | 8 | >128 | >32 | >128 | >32 | >8 | 0.5 | 1 | 16 |
| 9 | K. pneumoniae | >8 | >8 | >64 | >8 | >128 | >32 | >128 | >32 | >8 | 0.5 | 2 | >64 |
| 10 | K. pneumoniae | >8 | >8 | 64 | >8 | >128 | >32 | >128 | >32 | >8 | 1 | 2 | >64 |
| 11 | K. pneumoniae | >8 | >8 | 64 | >8 | >128 | >32 | >128 | >32 | >8 | 0.5 | 2 | >64 |
| 12 | K. pneumoniae | >8 | >8 | >64 | >8 | >128 | >32 | >128 | >32 | >8 | 0.5 | 2 | >64 |
| 13 | K. pneumoniae | >8 | >8 | 4 | 8 | >128 | >32 | 128 | >32 | >8 | 0.5 | 4 | >64 |
| 14 | Enterobacter aerogenes | 2 | 2 | 4 | 2 | >128 | <1 | <1 | 1 | <0.25 | 0.5 | <0.5 | <1 |
| 15 | K. pneumoniae | >8 | >8 | 8 | >8 | >128 | >32 | >128 | >32 | >8 | 0.5 | 4 | >64 |
| 16 | K. pneumoniae | >8 | >8 | 8 | >8 | >128 | >32 | >128 | >32 | >8 | 0.5 | 4 | >64 |
| 17 | K. pneumoniae | >8 | >8 | 2 | 8 | >128 | >32 | >128 | >32 | >8 | 0.5 | 4 | >64 |
| 18 | K. pneumoniae | >8 | >8 | 64 | >8 | >128 | >32 | >128 | >32 | >8 | 0.5 | 2 | >64 |
| 19 | K. pneumoniae | >8 | >8 | 8 | >8 | >128 | >32 | >128 | >32 | >8 | 2 | 1 | <1 |
| 20 | K. pneumoniae | >8 | >8 | 8 | >8 | >128 | >32 | >128 | >32 | >8 | 2 | 1 | <1 |
| 21 | K. pneumoniae | 2 | 0.25 | 2 | 0.5 | >128 | >32 | 64 | >32 | >8 | 0.5 | 1 | >64 |
| 22 | K. pneumoniae | >8 | >8 | 32 | >8 | >128 | >32 | >128 | >32 | >8 | 0.5 | 4 | >64 |
| 23 | K. pneumoniae | >8 | 4 | 4 | 4 | >128 | >32 | 128 | >32 | >8 | 0.5 | 4 | 64 |
| 24 | Escherichia coli | 4 | 0.5 | 2 | 0.5 | >128 | 8 | 2 | 8 | >8 | 0.5 | <0.5 | 2 |
| 25 | K. pneumoniae | >8 | 8 | 4 | 8 | >128 | 2 | <1 | 2 | <0.25 | 1 | <0.5 | <1 |
| 26 | K. pneumoniae | >8 | 8 | 4 | 8 | >128 | >32 | >128 | >32 | >8 | 0.5 | 1 | >64 |
| 27 | K. pneumoniae | >8 | 2 | 2 | 2 | >128 | >32 | 128 | >32 | >8 | 0.5 | 4 | <1 |
| 28 | K. pneumoniae | >8 | >8 | 4 | >8 | >128 | >32 | >128 | >32 | >8 | 1 | 1 | 8 |
| 29 | K. pneumoniae | >8 | >8 | 32 | >8 | >128 | >32 | >128 | >32 | >8 | 0.5 | <0.5 | 8 |
| 30 | K. pneumoniae | >8 | >8 | 8 | >8 | >128 | >32 | >128 | >32 | >8 | 0.5 | 1 | 8 |
*Not all drugs tested are listed. bla, β-lactamase; AMK, amikacin; CAZ, ceftazidime; CIP, ciprofloxacin; COL, colistin; CRO, ceftriaxone; DOR, doripenem; ETP, ertapenem; FEP, cefepime; IMP, imipenem; MEM, meropenem; TIG, tigecycline; TZP, piperacillin/tazobactam.
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