Volume 24, Number 4—April 2018
Research
Phenotypic and Genotypic Characterization of Enterobacteriaceae Producing Oxacillinase-48–Like Carbapenemases, United States
Joseph D. Lutgring
, Wenming Zhu, Tom J.B. de Man, Johannetsy J. Avillan, Karen F. Anderson, David R. Lonsway, Lori A. Rowe, Dhwani Batra, J. Kamile Rasheed, and Brandi M. Limbago
, Wenming Zhu, Tom J.B. de Man, Johannetsy J. Avillan, Karen F. Anderson, David R. Lonsway, Lori A. Rowe, Dhwani Batra, J. Kamile Rasheed, and Brandi M. Limbago
Table 4
Plasmid transformation of Enterobacteriaceae producing OXA-48–like carbapenemases, United States*
| Isolate no.† | MIC, μg/mL |
MHT MEM | OXA allele | Plasmid replicon type | ESBL CTX-M | ||||
|---|---|---|---|---|---|---|---|---|---|
| ETP | MEM | CRO | TZP | AMK | |||||
| R | <0.12 | <0.12 | <1 | <4 | <1 | – | |||
| 7 | >8 | >8 | >32 | >128 | 32 | + | 232 | ColKP3, IncR, IncFIB(pQIL) | 15 |
| 7T | >8 | 4 | <1 | >128 | <1 | + | 232 | ColKP3 | |
| 9 | >8 | >8 | >32 | >128 | >64 | + | 232 | ColKP3, IncR, IncHI1B, IncFIB(K) | 15 |
| 9T | >8 | 8 | <1 | >128 | <1 | + | 232 | ColKP3 | |
| 11 | >8 | >8 | >32 | >128 | >64 | + | 232 | ColKP3, IncR, IncHI1B, IncFIB(K) | 15 |
| 11T | >8 | 8 | ≤1 | >128 | <1 | + | 232 | ColKP3 | |
| 23 | >8 | 4 | >32 | >128 | 64 | + | 48 | IncL/M | 14b, 15 |
| 23T | 4 | 1 | >32 | >128 | 16 | + | 48 | IncL/M | 14b |
| 25 | >8 | 8 | 2 | >128 | <1 | + | 48 | IncL/M | |
| 25T | >8 | 8 | <1 | >128 | <1 | + | 48 | IncL/M | |
| 28 | >8 | >8 | >32 | >128 | 8 | + | 48 | IncL/M, IncR, ColRNAI | |
| 28T | >8 | 8 | <1 | 128 | <1 | + | 48 | IncL/M | |
*AMK, amikacin; CRO, ceftriaxone; ESBL, extended-spectrum β-lactamase; ETP, ertapenem; MEM, meropenem; MHT, modified Hodge test; OXA, oxacillinase; R, recipient strain before transformation (Escherichia coli DH10B); T, transformant; TZP, piperacillin/tazobactam; –, negative; +, positive.
†Isolates 1, 2, 26, and 27 did not have any transformants.
Page created: July 31, 2018
Page updated: July 31, 2018
Page reviewed: July 31, 2018
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