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Volume 24, Number 4—April 2018
Research

Evolution of Sequence Type 4821 Clonal Complex Meningococcal Strains in China from Prequinolone to Quinolone Era, 1972–2013

Qinglan Guo1, Mustapha M. Mustapha1, Mingliang Chen, Di Qu, Xi Zhang, Min ChenComments to Author , Yohei DoiComments to Author , Minggui WangComments to Author , and Lee H. Harrison
Author affiliations: Fudan University Huashan Hospital, Shanghai, China (Q. Guo, M. Wang); University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA (M.M. Mustapha, Y. Doi, L.H. Harrison); Shanghai Municipal Center for Disease Control and Prevention, Shanghai (M. Chen, X. Zhang, M. Chen); Fudan University Shanghai Medical College, Shanghai (D. Qu)

Main Article

Table

Recombinant genes unique to the Neisseria meningitidis clonal complex 4821 epidemic clone, China, 1972–1977 and 2005–2013*

Gene ID Gene name Annotation
NMCC_0090 ctrE Polysialic acid capsule modification protein LipA
NMCC_0091 ctrF Polysialic acid capsule modification protein LipB
NMCC_0136 Putative RmuC-like protein
NMCC_0137 Putative metallo-dependent hydrolase
NMCC_0138 Putative periplasmic DNA ligase (polydeoxyribonucleotide synthase [ATP])
NMCC_0140 ptsIIA Phosphotransferase system, enzyme IIA (protein IIA)
NMCC_0141 ptsH Phosphocarrier protein HPr (phosphotransferase system, histidine-containing protein)
NMCC_0142 ptsI Phosphoenolpyruvate-protein phosphotransferase (phosphotransferase system, enzyme I; protein I)
NMCC_0158 porB Major outer-membrane protein P.IB (protein IB; PIB; porin)
NMCC_0350 Putative peptidase
NMCC_0351 fHbp Factor H binding lipoprotein (lipoprotein GNA1870)
NMCC_0352 fba Fructose-bisphosphate aldolase
NMCC_1338 porA Major outer-membrane protein P.IA (protein IA; PIA; porin)
NMCC_1341 greA Transcription elongation factor GreA (transcript cleavage factor GreA)
NMCC_1342 aroA 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS)
NMCC_1343 Conserved hypothetical lipoprotein
NMCC_1363 Putative DnaQ-like exonuclease
NMCC_1364 Arg tRNA
NMCC_1365 Glu tRNA
NMCC_1366 Putative dioxygenase
NMCC_1367 Conserved hypothetical membrane protein
NMCC_1368 Putative ferredoxin
NMCC_1370 tkt Transketolase
NMCC_2038 fmt Methionyl-tRNA formyltransferase

*Gene IDs correspond to gene identifiers in the clonal complex 4821 reference genome 053442. ATP, adenosine triphosphate; EPSP, 5-enolpyruvylshikimate-3-phosphate; EPSPS, EPSP synthase; ID, identifier.

Main Article

1These authors contributed equally to this article.

Page created: March 28, 2018
Page updated: March 28, 2018
Page reviewed: March 28, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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