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Volume 24, Number 4—April 2018
Research

Cooperative Recognition of Internationally Disseminated Ceftriaxone-Resistant Neisseria gonorrhoeae Strain

Monica M. Lahra, Irene Martin, Walter Demczuk, Amy V. Jennison, Ken-Ichi Lee, Shu-Ichi Nakayama, Brigitte Lefebvre, Jean Longtin, Alison Ward, Michael R. Mulvey, Teodora Wi, Makoto Ohnishi, and David WhileyComments to Author 
Author affiliations: World Health Organization, Sydney, New South Wales, Australia (M.M. Lahra); University of New South Wales School of Medical Sciences, Sydney (M.M. Lahra); Public Health Agency of Canada, Winnipeg, Manitoba, Canada (I. Martin, W. Demczuk, M.R. Mulvey); Health Support Queensland, Brisbane, Queensland, Australia (A.V. Jennison); National Institute of Infectious Diseases, Tokyo, Japan (K.-I. Lee, S.-I. Nakayama, M. Ohnishi); Institut National de Sante Publique Québec, Ste-Anne-de-Bellevue, Quebec, Canada (B. Lefebvre, J. Longtin); Royal Adelaide Hospital, Adelaide, South Australia, Australia (A. Ward); World Health Organization, Geneva, Switzerland (T. Wi); National Institute of Infectious Diseases, Tokyo (M. Ohnishi); The University of Queensland Faculty of Medicine, Brisbane (D. Whiley)

Main Article

Figure

Core single-nucleotide variation (SNV) phylogenetic tree of ceftriaxone-resistant Neisseria gonorrhoeae isolates. The maximum-likelihood phylogenetic tree is rooted on the reference genome of N. gonorrhoeae FA1090 (GenBank accession no. NC_002946.2). Isolates are indicated by country and year. Strains F89, A8806, and H041 (World Health Organization [WHO] reference panel WHO-Y, WHO-Z, and WHO-X, respectively) are previously reported ceftriaxone-resistant reference strains (10). Scale bar indicate

Figure. Core single-nucleotide variation (SNV) phylogenetic tree of ceftriaxone-resistant Neisseria gonorrhoeae isolates. The maximum-likelihood phylogenetic tree is rooted on the reference genome of N. gonorrhoeae FA1090 (GenBank accession no. NC_002946.2). Isolates are indicated by country and year. Strains F89, A8806, and H041 (World Health Organization [WHO] reference panel WHO-Y, WHO-Z, and WHO-X, respectively) are previously reported ceftriaxone-resistant reference strains (10). Scale bar indicates estimated evolutionary divergence between isolates on the basis of average genetic distance between strains (estimated number of substitutions in the sample/total number of high-quality SNVs). MLST, multilocus sequence type; NG-MAST, Neisseria gonorrhoeae multiantigen sequence type; NG-STAR, Neisseria gonorrhoeae sequence type for antimicrobial resistance; PenA, penicillin-binding protein 2.

Main Article

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Page created: March 19, 2018
Page updated: March 19, 2018
Page reviewed: March 19, 2018
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