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Volume 24, Number 4—April 2018
Research

Cooperative Recognition of Internationally Disseminated Ceftriaxone-Resistant Neisseria gonorrhoeae Strain

Monica M. Lahra, Irene Martin, Walter Demczuk, Amy V. Jennison, Ken-Ichi Lee, Shu-Ichi Nakayama, Brigitte Lefebvre, Jean Longtin, Alison Ward, Michael R. Mulvey, Teodora Wi, Makoto Ohnishi, and David WhileyComments to Author 
Author affiliations: World Health Organization, Sydney, New South Wales, Australia (M.M. Lahra); University of New South Wales School of Medical Sciences, Sydney (M.M. Lahra); Public Health Agency of Canada, Winnipeg, Manitoba, Canada (I. Martin, W. Demczuk, M.R. Mulvey); Health Support Queensland, Brisbane, Queensland, Australia (A.V. Jennison); National Institute of Infectious Diseases, Tokyo, Japan (K.-I. Lee, S.-I. Nakayama, M. Ohnishi); Institut National de Sante Publique Québec, Ste-Anne-de-Bellevue, Quebec, Canada (B. Lefebvre, J. Longtin); Royal Adelaide Hospital, Adelaide, South Australia, Australia (A. Ward); World Health Organization, Geneva, Switzerland (T. Wi); National Institute of Infectious Diseases, Tokyo (M. Ohnishi); The University of Queensland Faculty of Medicine, Brisbane (D. Whiley)

Main Article

Table 1

Phenotypic and molecular characterization of ceftriaxone-resistant Neisseria gonorrhoeae*

Isolate ID
 Year
 Country (ref)
 MIC, mg/L
 MLST
 porB
 tbpB
 NG-MAST
 penA
 NG-STAR
CEF
 CFM
 SPX
 TET
CIP
 AZM
 GEN
 PCN
 β-lac, PPNG
FC428 2015 Japan (7) 0.5 1 8 0.5 >32 0.25 8 ≥32 + 1903 1053 21 3435 60.001 233
FC460 2015 Japan (7) 0.5 1 8 0.5 >32 0.25 8 ≥32 + 1903 1053 21 3435 60.001 233
GK124 2017 DEN (9) 0.5 1 8 NA >32 0.5 NA >256 NA 1903 1053 33 1614 NA NA
47707 2017 Canada (8) 1 2 16 4 32 0.5 8 ≥256 + 1903 1053 33 1614 60.001 233
A7846 2017 AUS
(This study) 0.5 NA 8 2 >32 0.25 4 ≥32 + 1903 1053 33 1614 60.001 233
A7536 2017 AUS
(This study) 0.5 NA 8 4 >32 0.25 4 ≥32 + 1903 9300 21 15925 60.001 233
F89 2010 France (3,10) 1 2 16 4 >32 1 8 1 – 1901 908 110 1407 42.001 16
A8806 2013 AUS (5,10) 0.5 2 16 4 >32 1 4 2 – 7363 1059 10 4015 64.001 227
H041 2009 Japan (2) 2 4 16 2 >32 0.5 4 4 – 7363 2594 10 4220 37.001 226

*AUS, Australia; AZM, azithromycin; β-lac, β-lactamase; CEF, ceftriaxone; CFM, cefixime; CIP, ciprofloxacin; DEN, Denmark; GEN, gentamicin; MLST, multilocus sequence type; NG-MAST, Neisseria gonorrhoeae multi-antigen sequence type; NG-STAR, Neisseria gonorrhoeae sequence type for antimicrobial resistance; NA, not available; PCN, penicillin; PPNG, penicillinase-producing N. gonorrhoeae; ref, reference; SPX, spectinomycin; TET, tetracycline; +, positive; –, negative.

Main Article

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Page updated: March 19, 2018
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