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Volume 24, Number 4—April 2018
Research

Cooperative Recognition of Internationally Disseminated Ceftriaxone-Resistant Neisseria gonorrhoeae Strain

Monica M. Lahra, Irene Martin, Walter Demczuk, Amy V. Jennison, Ken-Ichi Lee, Shu-Ichi Nakayama, Brigitte Lefebvre, Jean Longtin, Alison Ward, Michael R. Mulvey, Teodora Wi, Makoto Ohnishi, and David WhileyComments to Author 
Author affiliations: World Health Organization, Sydney, New South Wales, Australia (M.M. Lahra); University of New South Wales School of Medical Sciences, Sydney (M.M. Lahra); Public Health Agency of Canada, Winnipeg, Manitoba, Canada (I. Martin, W. Demczuk, M.R. Mulvey); Health Support Queensland, Brisbane, Queensland, Australia (A.V. Jennison); National Institute of Infectious Diseases, Tokyo, Japan (K.-I. Lee, S.-I. Nakayama, M. Ohnishi); Institut National de Sante Publique Québec, Ste-Anne-de-Bellevue, Quebec, Canada (B. Lefebvre, J. Longtin); Royal Adelaide Hospital, Adelaide, South Australia, Australia (A. Ward); World Health Organization, Geneva, Switzerland (T. Wi); National Institute of Infectious Diseases, Tokyo (M. Ohnishi); The University of Queensland Faculty of Medicine, Brisbane (D. Whiley)

Main Article

Table 2

PenA types identified in ceftriaxone-resistant Neisseria gonorrhoeae strains*

PenA type Strain ID Amino acid position in PenA protein (2,18)
34711111222222222223333333333333333333333333344444444444444444444555555555555555555
51000467000013678891112222223333444445777788800011134456666677888001111344455555677
 01403123440295811263467890125123563467836914702384882356903146251367323602367756
↑ ↑ ↑
0 M32091 MCAKDDVNYGEDQQAADRRAIVAGTDLNERLQPSPR.SRGAEFEITLNRRPAVLQIFESRENPTTAFANVAAHGGAPPKII.A
37 H041 ....E.ASHAGEE..VEKQVMPS.V.TTDTFL.ATQ.TMTPK.DVSV.K..VEVKVIA.KKEASI.LVY...N.ST.VQVVNV
42 F89 ....E.ASHAGEE..VEKQ.MTS.V.ATDTFLSATQ.TMTPK.DV..S.QKVEVKVIA.KKEA..PLVY...N.S........
60 FC428/ FC460/ A7536/
A7846/ 47707 ...................VMTS.V.PTDTFL.ATQ.TMTPK.DV..S.QKVEVKVIA.KKEASI.LVY...N.ST.VQVVNV
64 A8806 ....E.ASHAGEE......VMTS.V.PTDTFL.ATQ.TMTPK.DV..S.QKVEVKVIA.KKEASI.LVY...N.ST.VQVVNV

*Arrows indicate key amino acid positions associated with high level β-lactam resistance. PenA, penicillin-binding protein 2.

Main Article

References
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Page created: March 19, 2018
Page updated: March 19, 2018
Page reviewed: March 19, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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