Volume 24, Number 5—May 2018
Dispatch
Characterization of Clinical Isolates of Bartonella henselae Strains, South Korea
Table 1
Demographic and clinical characteristics of 5 case-patients whose serum sample cultures revealed the presence of Bartonella henselae, South Korea*
Characteristic | Case-patient 1 | Case-patient 2 | Case-patient 3 | Case-patient 4 (5) | Case-patient 5 (4) |
---|---|---|---|---|---|
Age, y/sex |
22/M |
40/F |
52/F |
42/M |
73/F |
Clinical symptoms |
Inguinal LAP, rash |
Fever, myalgia |
Febrile sense, left flank pain |
Rash, fever, myalgia |
Fever, general weakness |
Lymphadenopathy |
External iliac chain, inguinal area, supraclavicular area |
Left neck level IV, V |
Right neck II, III, VA |
Right supraclavicular area |
None |
Leukocytes, cells/µL |
10,920 |
6,130 |
8,180 |
19,260 |
5,120 |
AST/ALT, IU/dL |
132/270 |
107/51 |
30/16 |
212/246 |
47/56 |
ESR,mm/h/CRP, mg/dL |
21/3.93 |
44/5.5 |
4/0.14 |
25/12.9 |
22/13.16 |
Treatment |
Third-generation cephalosporin, doxycycline |
Levofloxacin, metronidazole, third-generation cephalosporin and doxycycline |
Third-generation cephalosporin, minocycline, metronidazole |
Doxycycline, changed to minocycline |
Third-generation cephalosporin, doxycycline |
B. henselae IgG titer |
1:160 |
1:640 |
1:160 |
1:1,280 |
1:160 |
Pets |
None |
None |
None |
None |
None |
Co-occurring conditions |
None |
Pulmonary tuberculosis |
None |
None |
None |
*ALT, alanine aminotransferase; AST, aspartate aminotransferase; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate. |
References
- Maggi RG, Mozayeni BR, Pultorak EL, Hegarty BC, Bradley JM, Correa M, et al. Bartonella spp. bacteremia and rheumatic symptoms in patients from Lyme disease-endemic region. Emerg Infect Dis. 2012;18:783–91. DOIPubMedGoogle Scholar
- Nelson CA, Saha S, Mead PS. Cat-Scratch Disease in the United States, 2005-2013. Emerg Infect Dis. 2016;22:1741–6. DOIPubMedGoogle Scholar
- Chung JY, Han TH, Kim BN, Yoo YS, Lim SJ. Detection of bartonella henselae DNA by polymerase chain reaction in a patient with cat scratch disease: a case report. J Korean Med Sci. 2005;20:888–91. DOIPubMedGoogle Scholar
- Im JH, Baek JH, Lee HJ, Lee JS, Chung MH, Kim M, et al. First case of Bartonella henselae bacteremia in Korea. Infect Chemother. 2013;45:446–50. DOIPubMedGoogle Scholar
- Durey A, Kwon HY, Im JH, Lee SM, Baek J, Han SB, et al. Bartonella henselae infection presenting with a picture of adult-onset Still’s disease. Int J Infect Dis. 2016;46:61–3. DOIPubMedGoogle Scholar
- La Scola B, Raoult D. Culture of Bartonella quintana and Bartonella henselae from human samples: a 5-year experience (1993 to 1998). J Clin Microbiol. 1999;37:1899–905.PubMedGoogle Scholar
- Lane DJ. 16S/23S rRNA sequencing. In: Stackebrandt E, Goodfellow M, editors. Nucleic acid techniques in bacterial systematics. Chichester (UK): Wiley; 1991. p. 115–75.
- Tamura K, Nei M. Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. Mol Biol Evol. 1993;10:512–26.PubMedGoogle Scholar
- Tamura K, Stecher G, Peterson D, Filipski A, Kumar S. MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Mol Biol Evol. 2013;30:2725–9. DOIPubMedGoogle Scholar
- Iredell J, Blanckenberg D, Arvand M, Grauling S, Feil EJ, Birtles RJ. Characterization of the natural population of Bartonella henselae by multilocus sequence typing. J Clin Microbiol. 2003;41:5071–9. DOIPubMedGoogle Scholar
- Sykes JE, Lindsay LL, Maggi RG, Breitschwerdt EB. Human coinfection with Bartonella henselae and two hemotropic mycoplasma variants resembling Mycoplasma ovis. J Clin Microbiol. 2010;48:3782–5. DOIPubMedGoogle Scholar
- dos Santos AP, dos Santos RP, Biondo AW, Dora JM, Goldani LZ, de Oliveira ST, et al. Hemoplasma infection in HIV-positive patient, Brazil. Emerg Infect Dis. 2008;14:1922–4. DOIPubMedGoogle Scholar
- Dillon B, Valenzuela J, Don R, Blanckenberg D, Wigney DI, Malik R, et al. Limited diversity among human isolates of Bartonella henselae. J Clin Microbiol. 2002;40:4691–9. DOIPubMedGoogle Scholar
1These authors contributed equally to this article.