Diversity of Influenza A(H5N1) Viruses in Infected Humans, Northern Vietnam, 2004–2010
, Jorge M. Dinis1
, Gongxun Zhong, Louise H. Moncla, Tiago J.S. Lopes, Ryan McBride, Andrew J. Thompson, Wenjie Peng, Mai thi Q. Le, Anthony Hanson, Michael Lauck, Yuko Sakai-Tagawa, Shinya Yamada, Julie Eggenberger, David H. O’Connor, Yasuo Suzuki, Masato Hatta, James C. Paulson, Gabriele Neumann, and Yoshihiro Kawaoka
Author affiliations: University of Wisconsin, Madison, Wisconsin, USA (H. Imai, J.M. Dinis, G. Zhong, L.H. Moncla, T.J.S. Lopes, A. Hanson, M. Lauck, J. Eggenberger, D.H. O’Connor, M. Hatta, G. Neumann, T.C. Friedrich, Y. Kawaoka); The Scripps Research Institute, La Jolla, California, USA (R. McBride, A.J. Thompson, W. Peng, J.C. Paulson); National Institute of Hygiene and Epidemiology, Hanoi, Vietnam (M.t.Q. Le); University of Tokyo, Tokyo, Japan (Y. Sakai-Tagawa, S. Yamada, Y. Kawaoka); Chubu University, Kasugai, Japan (Y. Suzuki)
Figure 1. Frequencies of nonsynonymous single-nucleotide polymorphisms detected in >5% of sequence reads obtained from humans infected with influenza A(H5N1) virus, northern Vietnam, 2004–2010. Bar graphs depict the percentages of the indicated single-nucleotide polymorphisms from TS or TA samples. The amino acids at the respective positions are shown by the single-letter code. HA-54(+1) refers to an H5 HA amino acid insertion after position 54 that was not found in H3 HAs (which was used as a reference for the numbering of HA amino acid positions). HA, hemagglutinin; NP, nucleocapsid; NS, nonstructural; PA, polymerase acidic; PB, polymerase basic; TA, tracheal aspirate; TS, throat swab.
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