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Volume 24, Number 7—July 2018

Guiana Dolphin Unusual Mortality Event and Link to Cetacean Morbillivirus, Brazil

Kátia R. GrochComments to Author , Elitieri B. Santos-Neto, Josué Díaz-Delgado, Joana M.P. Ikeda, Rafael R. Carvalho, Raissa B. Oliveira, Emi B. Guari, Tatiana L. Bisi, Alexandre F. Azevedo, José Lailson-Brito, and José L. Catão-Dias
Author affiliations: Universidade de São Paulo, São Paulo, Brazil (K.R. Groch, J. Díaz-Delgado, J.L. Catão-Dias); Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil (E.B. Santos-Neto, J.M.P. Ikeda, R.R. Carvalho, R.B. Oliveira, E.B. Guari, T.L. Bisi, A.F. Azevedo, J. Lailson-Brito)

Main Article

Table 2

Summary of histopathologic findings for 6 Guiana dolphins recovered from Ilha Grande Bay, Rio de Janeiro, Brazil, 2017*

No. Tissue Histopathologic findings
1† Lung Marked, multifocal chronic bronchointerstitial pneumonia and proliferative pleuritis with sclerosis, type II pneumocyte hyperplasia, syncytia/multinucleated cells, rare INCIBs, calcified nematode debris and edema; multifocal tunica media hypertrophy/hyperplasia
Mammary gland Mild to moderate, multifocal, chronic lymphoplasmacytic and histiocytic mastitis with acinar ectasia, inspissated secretion, scattered necrosis, ceroid pigment and moderate INCIBs in epithelium
Heart Mild, focal, subacute fibrinous pericarditis; mild, multifocal myocardial fibrosis
Kidney Mild, multifocal, chronic membranous glomerulonephritis with glomerulocysts, tubular proteinosis, protein casts, and scattered tubuloepithelial necrosis
Pulmonary lymph node Mild, multifocal, chronic nodular eosinophilic and necrotizing lymphadenitis with fibrosis and hemosiderosis; diffuse lymphoid depletion
Mediastinal lymph node Mild, multifocal, chronic eosinophilic lymphadenitis; diffuse congestion
Spleen Diffuse congestion and multifocal, acute capsular hemorrhage; extramedullary hematopoiesis
Adrenal Mild, multifocal, acute corticomedullary hemorrhage
Aorta Mild, segmental, chronic proliferative endarteritis
Liver Moderate, multifocal, chronic bile duct adenomatous hyperplasia
Uterus Moderate, multifocal, chronic arteriosclerosis and arterial elastosis

Glandular stomach
Mild, diffuse mucosal hyperplasia; multifocal arterial tunica media hypertrophy/hyperplasia
2‡ Lung Mild, multifocal, acute interstitial pneumonia associated with marked alveolar edema, hemorrhage and alveolar histiocytosis, syncytia/multinucleated cells and keratin spicules
Kidney Mild, multifocal, acute tubular degeneration and necrosis; mild, multifocal, acute tubular proteinosis and protein casts; marked, focal, acute perirenal hemorrhage
Pulmonary lymph node Moderate, diffuse cortical and paracortical lymphoid depletion with scattered lymphocytolysis
Prescapular lymph node Diffuse congestion with focal acute hemorrhage and erythrophagocytosis; sinus vascularization
Spleen Moderate, diffuse, lymphoid depletion with sinus histiocytosis; extramedullary hematopoiesis
Heart Moderate, multifocal, acute subendocardial and epicardial hemorrhage
Adrenal Marked, multifocal, acute cortico-medullary hemorrhagic necrosis
Esophagus Focal acute hemorrhage in serosa
Urinary bladder Edema and focal acute hemorrhage in serosa
Penis Urethral luminal hemorrhage with single cell epithelial necrosis/apoptosis

Cerebrum, cerebellum
Diffuse leptomeningeal congestion and perivascular edema in neuroparenchyma
10§ Lung Mild to moderate, multifocal, chronic suppurative bronchopneumonia with adult nematodes (Halocercus sp.); multifocal alveolar, bronchiolar and bronchial mineralization
Keratinized stomach Mild, focal, chronic proliferative gastritis

Skeletal muscle
Scattered acute hyaline myocyte degeneration and necrosis
11 Ascending aorta Marked, segmental, chronic fibrosing and proliferative endarteritis with chondroid metaplasia and calcification; moderate, focal, chronic granulomatous periarteritis; mild, multifocal intimal fibroelastosis

Aortic (semilunar) valve
Mild, multifocal, chronic intimal/endocardial fibroelastosis
Keratinized stomach
Mild, focal, chronic mononuclear gastritis
13# Lung Marked, multifocal, chronic suppurative to pyogranulomatous bronchopneumonia with bronchial/olar sclerosis, adult and larval nematodes (Halocercus sp.) and moderate, multifocal, chronic proliferative and fibrosing (villous) pleuritis; marked, multifocal, chronic tunica media arterial hypertrophy/hyperplasia with stenosis
Skin Mild, multifocal, chronic irregular epidermal hyperplasia
Pyloric stomach Moderate, focal, chronic granulomatous gastritis with numerous trematode ova (compatible with Pholeter gastrophilus)

*INCIBs, intranuclear and intracytoplasmic inclusion bodies; no., animal no.
†No significant lesions were observed for large intestine, thyroid, skin, trachea, cerebrum, cerebellum, spinal cord, or skeletal muscle.
‡No significant lesions were observed for keratinized and pyloric stomach, tongue, aorta, small intestine, pancreas, or trachea.
§Unable to observe lesions in liver, spleen, kidney, testicle, trachea, small and large intestine, skin, periaortic lymph node, cerebrum, or cerebellum because of advanced autolysis of animal.
¶Unable to observe lesions in ovary, skin, liver, skeletal muscle, heart, kidney, spleen, large intestine, bladder, lymph node, or adrenal gland because of advanced autolysis of animal.
#Unable to observe lesions in small intestine, liver, skeletal muscle, adrenal gland, bladder, kidney, or heart because of advanced autolysis of animal.

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Page created: June 18, 2018
Page updated: June 18, 2018
Page reviewed: June 18, 2018
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