Volume 24, Number 8—August 2018
Case Definition of Chronic Pulmonary Aspergillosis in Resource-Constrained Settings
|Symptoms for >3 mo||Hemoptysis and/or persistent cough and/or weight loss; Other symptoms are common, but not requred, notably fatigue, chest pain, dyspnea, and sputum production|
|Radiologic features||Progressive cavitation on chest imaging and/or intracavitary fungal ball and/or pleural thickening or pericavitary fibrosis or infiltrates all adjacent to cavities|
|Microbiological evidence of Aspergillus infection||Positive Aspergillus-specific IgG and/or sputum microscopy results showing hyphae consistent with Aspergillus and/or Aspergillus growth on >2 sputum or other respiratory samples|
|Mycobacterial infection ruled out with smear, GeneXpert, and/or mycobacterial culture‡||It is possible for mycobacterial infection and CPA to be present concurrently, but this diagnosis requires characteristic radiological findings on CT scan that are not present with pulmonary TB including pleural thickening, a fungal ball or other intracavitary material, or marked pericavitary infiltrates in addition to a positive Aspergillus IgG antibody test|
*CPA, chronic pulmonary aspergillosis; CT, computed tomography; TB, tuberculosis.
†All 4 criteria are required.
Page created: July 17, 2018
Page updated: July 17, 2018
Page reviewed: July 17, 2018
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