Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 24, Number 8—August 2018

Case Series of Severe Neurologic Sequelae of Ebola Virus Disease during Epidemic, Sierra Leone

Patrick J. HowlettComments to Author , Anna R. Walder, Durodami R. Lisk, Felicity Fitzgerald, Stephen Sevalie, Marta Lado, Abdul N’jai, Colin S. Brown, Foday Sahr, Foday Sesay, Jonathon M. Read, Paul J. Steptoe, Nicholas A.V. Beare, Reena Dwivedi, Marylou Solbrig, Gibrilla F. Deen, Tom Solomon, Malcolm G. Semple, and Janet T. Scott
Author affiliations: King's College London & King's Health Partners, London, UK (P.J. Howlett, A.R. Walder, M. Lado, C.S. Brown); University of Sierra Leone, Freetown, Sierra Leone (D.R. Lisk, A. N’jai, G.F. Deen); University College London Great Ormond Street Institute of Child Health, London (F. Fitzgerald); Save the Children, United Kingdom and Sierra Leone, London (F. Fitzgerald); University of Nairobi, Nairobi, Kenya (S. Sevalie); 34th Military Hospital, Republic of Sierra Leone Joint Armed Forces Joint Medical Unit, Freetown (S. Sevalie, F. Sahr, F. Sesay); Lancaster University, Lancaster, UK (J.M. Read); University of Liverpool, Liverpool, UK (J.M. Read, P.J. Steptoe, N.A.V. Beare, M.G. Semple, J.T. Scott); Royal Liverpool University Hospital, Liverpool (N.A.V. Beare, R. Dwivedi); University of Manitoba, Winnipeg, Manitoba, Canada (M. Solbrig); Institute of Global Health, Walton Centre NHS Foundation Trust, Liverpool (T. Solomon)

Main Article

Table 3

Demographics, clinical characteristics during acute admission, and cycle threshold of preliminary clinic group in study of severe neurologic sequelae among Ebola virus disease survivors, by those who had severe and those who had no severe neurologic conditions, Sierre Leone*

Characteristic No severe neurologic features, n = 21 Severe neurologic features, n = 19 Crude odds ratio† (95% CI)
Age, y, median (IQR) 28 (23–60) 32 (25–42) 0.01 (0.00–0.036)/y
Female sex, % (95% CI) 48 (43–54) 68 43–87 2.3 (0.79–7.60)
Length of stay, d, median (IQR) 18 (14–28) 25 (13–29) 0.02/d

Seizures during admission, % (95% CI) 19 (5–42) 21 (6–46) 1.13 (0.18–7.23)
Unconscious during admission, % (95% CI) 33 (15–57) 63 (38–83) 3.32 (0.79–15.4)
Bleeding during admission, % (95% CI) 19 (5–42) 5 (0.1–26) 0.24 (0.00–2.80)
Cycle threshold, median (IQR) 22.8 (22.1–24.1), n = 9 27.2 (22.5–30.1), n = 10 0.22 (0.7–1.3) for each increment

*Severe conditions were those requiring specialist referral.
†Odds ratio of patients having severe neurologic features compared with those who did not.

Main Article

Page created: July 17, 2018
Page updated: July 17, 2018
Page reviewed: July 17, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.