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Volume 24, Number 8—August 2018
Research

Novel Enterobacter Lineage as Leading Cause of Nosocomial Outbreak Involving Carbapenemase-Producing Strains

Racha Beyrouthy, Marion Barets, Elodie Marion, Cédric Dananché, Olivier Dauwalder, Frédéric Robin, Lauraine Gauthier, Agnès Jousset, Laurent Dortet, François Guérin, Thomas Bénet, Pierre Cassier, Philippe Vanhems1, and Richard Bonnet1Comments to Author 
Author affiliations: Centre Hospitalier Universitaire, Clermont-Ferrand, France (R. Beyrouthy, F. Robin, R. Bonnet); Centre National de Référence de la Résistance aux Antibiotiques, Clermont-Ferrand (R. Beyrouthy, F. Robin, R. Bonnet); Université Clermont Auvergne, Clermont-Ferrand (R. Beyrouthy, F. Robin, R. Bonnet); Institut National de la Santé et de la Recherche Médicale, Clermont-Ferrand (R. Beyrouthy, F. Robin, R. Bonnet); Institut National de la Recherche Agronomique, Clermont-Ferrand (R. Beyrouthy, F. Robin, R. Bonnet); Hôpital Édouard Herriot, Hospices Civils de Lyon, Lyon, France (M. Barets, E. Marion, C. Dananché, T. Bénet, P. Cassier, P. Vanhems); Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon (O. Dauwalder); Centre International de Recherche en Infectiologie, Lyon (O. Dauwalder, T. Bénet, P. Vanhems),; Centre Hospitalier Universitaire Bicêtre, Paris, France (L. Gauthier, A. Jousset, L. Dortet); Centre National de Référence Associé de la Résistance aux Antibiotiques, Paris (L. Gauthier, A. Jousset, L. Dortet); Centre Hospitalier Universitaire, Caen, France (F. Guérin)

Main Article

Table 2

Key features of clinical VIM-4–producing Enterobacter cloacae complex isolates in nosocomial outbreak involving carbapenamase-producing strains, Lyon, France, January 12, 2014–December 31, 2015*

Isolate
 Species
 ST
 hsp60 cluster
(phylogenome)
 Size of assembled genomes, bp
 MICs, mg/L
ETP
 IPM
 MEM
 CAZ
 CTX
 FEP
 ATM
C45 E. cloacae complex 873 NA (S) 5,290,194 2 2 1 32 >32 4 4
C46 E. cloacae complex 873 NA (S) 5,257,311 2 1 0.5 24 >32 2 4
C48 E. cloacae complex 873 NA (S) 5,260,873 2 2 0.5 24 >32 2 4
C310 E. cloacae complex 873 NA (S) 5,254,482 2 2 1 24 >32 2 2
E14 E. cloacae complex 873 NA (S) 5,251,662 2 2 1 32 >32 4 4
E16 E. cloacae complex 873 NA (S) 5,250,845 2 2 1 32 >32 4 4
C47 E. cloacae cluster III 118 III (D) 5,083,854 2 2 0.5 16 >32 2 0.25
C308 E. cloacae cluster III 118 III (D) 4,998,377 2 1 0.25 32 >32 2 0.5
C309
 E. hormaechei steigerwaltii
 110
 VIII (B)
 5,200,769
 4
 2
 0.5
 96
 >32
 8
 32
*ATM, aztreonam; CAZ, ceftazidime; CTX, cefotaxime; ETP, ertapenem; FEP; IPM, imipenem; MEM, meropenem; NA, not applicable; ST, sequence type.

Main Article

1These authors contributed equally to this article.

Page created: July 18, 2018
Page updated: July 18, 2018
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