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Volume 24, Number 9—September 2018

Maripa Virus RNA Load and Antibody Response in Hantavirus Pulmonary Syndrome, French Guiana

Séverine MatheusComments to Author , Hatem Kallel, Alexandre Roux, Laetitia Bremand, Bhety Labeau, David Moua, Dominique Rousset, Damien Donato, Vincent Lacoste, Stéphanie Houcke, Claire Mayence, Benoît de Thoisy, Didier Hommel, and Anne Lavergne
Author affiliations: Institut Pasteur de la Guyane, Cayenne, French Guiana (S. Matheus, L. Bremand, B. Labeau, D. Moua, D. Rousset, D. Donato, V. Lacoste, B. de Thoisy, A. Lavergne); Centre Hospitalier de Cayenne, Cayenne (H. Kallel, A. Roux, S. Houcke, C. Mayence, D. Hommel)

Main Article

Table 1

Immune response and viral loads on admission in 6 confirmed hantavirus cases, French Guiana*

Characteristic Patient 1 Patient 2 Patient 3 Patient 4 Patient 5 Patient 6
Year case reported 2008 2009 2010 2013 2016 2017
Age, y 38 56 49 67 71 47
Days of disease at admission 7 4 2 4 4 7
SNV IgM Positive Positive Positive Positive Positive Positive
IgM sum OD† 1.02 1.70 4.72 0.92 2.23 1.79
SNV IgG Negative Negative Negative Negative Positive Negative
IgG sum OD† 0.05 0.01 0.01 0.01 2.05 0.73
Serum viral RNA load‡ 5.8 6.6 6.4 5.9 6.0 6.4
Clinical evolution Favorable Death Death Death Death Favorable

*OD, optical density; SNV, Sin Nombre virus.
†Adjusted sum OD values (dilution 1:100, 1:400, 1:1,600, and 1:6,400).
‡Virus copy number was determined as log10 copies/mL. Primers and TaqMan probe for quantitative PCR were Maripa_qRT2F 5'-GCAGCTGTGTCTACATTGGAGAA-3', Maripa_qRT2R 5'-CCACCAGATCCGCCAACT-3', and Maripa_Probe2 5'-FAM-AAACTTGCAGAACTCA-MGB-3'.

Main Article

Page created: August 15, 2018
Page updated: August 15, 2018
Page reviewed: August 15, 2018
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