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Volume 24, Number 9—September 2018
Dispatch

Maripa Virus RNA Load and Antibody Response in Hantavirus Pulmonary Syndrome, French Guiana

Séverine MatheusComments to Author , Hatem Kallel, Alexandre Roux, Laetitia Bremand, Bhety Labeau, David Moua, Dominique Rousset, Damien Donato, Vincent Lacoste, Stéphanie Houcke, Claire Mayence, Benoît de Thoisy, Didier Hommel, and Anne Lavergne
Author affiliations: Institut Pasteur de la Guyane, Cayenne, French Guiana (S. Matheus, L. Bremand, B. Labeau, D. Moua, D. Rousset, D. Donato, V. Lacoste, B. de Thoisy, A. Lavergne); Centre Hospitalier de Cayenne, Cayenne (H. Kallel, A. Roux, S. Houcke, C. Mayence, D. Hommel)

Main Article

Table 2

Monitoring of hantavirus antibodies and viral RNA load in sequential serum samples from patient 6, French Guiana*

Characteristic
 Days after symptom onset
Day 7
 Day 12
 Day 15
 Day 20
 Day 25
 Day 30
 Day 46
SNV IgM
 Positive
 Positive
 Positive
 Positive
 Positive
 Positive
 Negative
IgM sum OD†
 1.79
 1.56
 1.50
 1.34
 1.01
 0.72
 0.42
SNV IgG
 Negative
 Positive
 Positive
 Positive
 Positive
 Positive
 Positive
IgG sum OD†
 0.73
 1.83
 2.20
 3.08
 4.21
 4.71
 4.40
Serum viral RNA load‡ 6.4 5.4 4.7 4.1 4.0 4.1 0

*OD, optical density; SNV, Sin Nombre virus.
†Adjusted sum OD values (dilution 1:100, 1:400, 1:1,600, and 1:6,400).
‡Virus copy number was determined as logs10 copies/mL. real-time PCR Primers and TaqMan probe for quantitative PCR were Maripa_qRT2F 5'-GCAGCTGTGTCTACATTGGAGAA-3', Maripa_qRT2R 5'-CCACCAGATCCGCCAACT-3', and Maripa_Probe2 5'-FAM-AAACTTGCAGAACTCA-MGB-3'.

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Page created: August 15, 2018
Page updated: August 15, 2018
Page reviewed: August 15, 2018
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