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Volume 25, Number 10—October 2019
CME ACTIVITY - Synopsis

Case Studies and Literature Review of Pneumococcal Septic Arthritis in Adults

Amandine Dernoncourt1Comments to Author , Youssef El Samad, Jean Schmidt, Jean Philippe Emond, Charlotte Gouraud, Anne Brocard, Mohamed El Hamri, Claire Plassart, Florence Rousseau, Valéry Salle, Momar Diouf, Emmanuelle Varon, and Farida Hamdad1
Author affiliations: Amiens-Picardie University Medical Center, Amiens, France (A. Dernoncourt, Y. El Samad, J. Schmidt, J.P. Emond, A. Brocard, M. El Hamri, C. Plassart, F. Rousseau, V. Salle, M. Diouf, F. Hamdad); Compiègne Hospital, Compiègne, France (J.P. Emond, C. Gouraud); Senlis Hospital, Senlis, France (A. Brocard); Laon Hospital, Laon, France (M. El Hamri); Beauvais Hospital, Beauvais, France (C. Plassart); Intercommunal Hospital of Creteil, Paris, France (E. Varon)

Main Article

Table 5

Detailed analysis of reports of septic arthritis in patients >18 years of age reported in medical literature during 1950–2019*

Study details Study authors, year published (reference)
This study Ros, et al., 2003 (10) Ispahani et al., 1999 (8) Dubost et al., 2004 (4) Raad et al., 2004 (6) James et al., 2000 (7) Belkhir et al., 2014 (9) Marrie et al., 2017 (16)
No. patients 16 11 25 7 4 14 9 51
Median age, y (IQR) 69.7 (+25) 60 (+18.5) 69 (NA) 63 (NA) 47 (+3.25) 63 (+21.75) 75 (+26) 56 (+17)
Sex, M/F
 7/9
 6/5
 11/14
 4/3
 2/2
 9/5
 4/5
 35/16
Impaired joints, no.
Knee 11 6 12 4 0 10 7 26
Hip 2 0 0 0 2 0 0 0
>1 joint 2 3 5 0 3 6 0 9
Prosthetic joint
 5
 2
 2
 0
 0
 0
 0
 NA
Extraarticular infections, no. 6† 5 11 1 2 7 5 NA
Underlying conditions, no.
 11†
 9
 23
 5
 4
 10
 3
 48
Known vaccination status, no. 11 0 0 0 0 0 1 0
No. immunized
 2
 –
 –
 –
 –
 –
 0
 –
Laboratory data, no. positive/no. tested
Bacteremia 11/16 9/11 20/24 4/6 1/4 8/14 5/9 51/51
Gram stain 11/14 NA 23/25 4/5 NA NA 5/9 NA
Culture
 14/15
 11/11
 19/25
 7/7
 4/4
 13/14
 7/9
 NA
Serotypes, no. 6 1 1 NA NA NA 4 29
Strains 23B and 24F 6A 24F – – – NA NA
Covered by PCV13
and PPV23
 N
 Y
 N
 –
 –
 –
 Y
Susceptibility
Penicillin S 4 3 25 NA 2 NA 5 NA
Ceftriaxone S 1 1 25 NA 1 1 NA NA
Ceftriaxone R
 1
 –
 –
 –
 –
 –
 NA
 NA
Median duration of antimicrobial therapy, d 42 42 49 27 49 NA 44.7 NA
Surgical intervention, no.‡
 6†
 8†
 21
 3
 2
 11
 6
 NA
Clinical outcome
Death 1 2 8 0 0 3 1 6
Sequelae 5 4 10 4 1 2 1 NA

*IQR, interquartile range; NA, not available; PCV13, pneumococcal 13-valent conjugate vaccine; PPV23, pneumococcal 23-valent polysaccharide vaccine; R, resistant; S, susceptible.
†Data not available for all patients in study.
‡Including arthrotomy or synovectomy of affected joint or prosthetic joint replacement.

Main Article

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Main Article

1These authors contributed equally to this article.

Page created: September 12, 2019
Page updated: September 12, 2019
Page reviewed: September 12, 2019
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