Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 25, Number 10—October 2019

Antigenic Variation of Avian Influenza A(H5N6) Viruses, Guangdong Province, China, 2014–2018

Ru Bai1, Reina S. Sikkema1, Cong rong Li, Bas B. Oude Munnink, Jie Wu, Lirong Zou, Yi Jing, Jing Lu, Runyu Yuan, Ming Liao, Marion P.G. Koopmans1Comments to Author , and Chang-wen Ke1Comments to Author 
Author affiliations: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China (R. Bai, C. Li, J. Wu, L. Zou, Y. Jing, J. Lu, R. Yuan, C. Ke); Erasmus Medical Centre, Rotterdam, the Netherlands (R.S. Sikkema, B.B. Oude Munnink, M.P.G. Koopmans); Southern Medical University Guangzhou (C. Li, Y. Jing, C. Ke); South China Agricultural University, Guangzhou (M. Liao)

Main Article


HI titers of influenza A(H5N6) virus strains collected during 2014–2018 in Guangdong Province, China, compared with vaccine strains*

Virus strain† Sample type Collection date HI titers
Postvaccination chicken serum
H5N6-infected human serum
S1 S2 S3 S4 S5 S6
39715 Human 2014 Dec 11 512 512 1024 512 256 16
ZQ874 Human 2015 Dec 31 512 512 512 512 256 16
HA256 Human 2017 Jun 30‡ 256 256 512 256 256 64
18SF020-1 Human 2018 Sep 30 32 16 64 32 16 64
C17280709 Environment 2017 May 2 64 64 128 128 64 16
C18277136 Environment 2018 Apr 2 64 32 32 64 16 16
C18285099 Environment 2018 Feb 28 32 32 NT NT 32 8
PO17284158 Waterfowl 2018 May 10 128 64 NT NT NT NT
Chicken 2018 Nov 19¶ 2,048 1,024 4,096 1,024 1,024 NT
B# Chicken 2018 Sep 20** 32 32 NT NT NT NT

*NT, not tested; S, sample no.
†The name of virus strain is the abbreviation of the original name for each viral isolate.
‡Date isolate received.
§Vaccine strain A/chicken/Guizhou/4/2013 (Re-8) + H7 A/pigeon/Shanghai/S1069/2013 (Re-1).
¶Date vaccine strain tested.
#Vaccine strain H5 A/duck/Guangdong/S1322/2010 (Re-6).
**Date vaccine strain received.

Main Article

1These authors contributed equally to this article.

Page created: September 17, 2019
Page updated: September 17, 2019
Page reviewed: September 17, 2019
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.