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Volume 25, Number 11—November 2019
Research

Clinical and Molecular Epidemiology of Invasive Group B Streptococcus Disease among Infants, China

Wenjing Ji , Haiying LiuComments to Author , Shabir A. Madhi, Marianne Cunnington, Zilu Zhang, Ziyaad Dangor, Haijian Zhou, Xiaoping Mu, Zhengjiang Jin, Aimin Wang, Xiaosong Qin, Chunyan Gao, Yuning Zhu, Xiaodan Feng, Shangyang She, Shuhua Yang, Jing Liu, Jine Lei, Lan Jiang, Zeshi Liu, Gang Li, Qiuhong Li, Qiulian Deng, Kankan Gao, and Yu Fang Comments to Author 
Author affiliations: Xi’an Jiaotong University, Xi’an, China (W. Ji, Y. Fang); Guangzhou Medical University, Guangzhou, China (H. Liu, Q. Deng, K. Gao); University of the Witwatersrand, Johannesburg, South Africa (S.A. Madhi, Z. Dangor); GlaxoSmithKline Plc, London, UK (M. Cunnington); Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA (Z. Zhang); Chinese Center for Disease Control and Prevention, Beijing, China (H. Zhou); Guangzhou Medical University, Guangzhou (X. Mu); Hubei Maternal and Child Health Hospital, Wuhan, China (Z. Jin); Children’s Hospital of Fudan University, Shanghai, China (A. Wang); China Medical University, Shenyang, China (X. Qin); Tangshan Maternal and Child Health Care Hospital, Tangshan, China (C. Gao); Zhejiang University, Hangzhou, China (Y. Zhu); Nanjing Maternity and Child Health Care Hospital, Nanjing, China (X. Feng); Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanjing (S. She); Tianjin Central Hospital of Gynecology Obstetrics, Tianjin, China (S. Yang); Tsinghua University Hospital, Beijing (J. Liu); The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an (J. Lei); Maternal and Child Health Care Hospital of Uygur Autonomous Region, Urumqi, China (L. Jiang); The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an (Z. Liu); General Hospital of Ningxia Medical University, Yinchuan, China (G. Li); Chongqing Health Center for Women and Children, Chongqing, China (Q. Li)

Main Article

Table 2

Live births and incidence of invasive GBS disease among infants <3 months of age, by region and sentinel hospital, China, January 1, 2015–December 31, 2017*

Region Births Case-patients born in sentinel hospitals Expected cases/ region† Hospital‡ Live births Expected cases/ hospital†
GBS case-patients born
GBS cases
 in study hospitals
Total EOD LOD Total EOD LOD
NE
 41,088
 16 (0.39)
 31
 SY§ 32,666 34 16 18 16 (0.49) 11 (0.34) 5 (0.15) 25
HY§
 8,422
 0
 0
 0
0
 0
 0
 6
North
 115,310
 21 (0.18)
 88
 BJ 43,099 3 3 0 3 (0.07) 3 (0.07) 0 33
TJ 42,320 7 5 2 6 (0.14) 5 (0.12) 1 (0.02) 32
TS
 29,891
 23
 7
 16
12 (0.40)
 4 (0.13)
 8 (0.27)
 23
East
 127,474
 28 (0.22)
 97
 NJ 70,153 16 4 12 14 (0.20) 4 (0.06) 10 (0.14) 53
ZJ
 57,321
 14
 12
 2
14 (0.24)
 12 (0.21)
 2 (0.03)
 44
Central
 108,175
 57 (0.53)
 82
 CS 40,521 19 15 4 19 (0.47) 15 (0.37) 4 (0.10) 31
HB
 67,654
 38
 17
 21
38 (0.56)
 17 (0.25)
 21 (0.31)
 51
South
 157,949
 76 (0.48)
 120
 GZ 66,477 74 18 56 36 (0.54) 12 (0.18) 24 (0.36) 51
GD 40,628 36 24 12 31 (0.76) 23 (0.57) 8 (0.20) 31
GX
 50,844
 13
 10
 3
9 (0.18)
 8 (0.16)
 1 (0.02)
 39
West
 84,535
 1 (0.01)
 64
 NX§ 8,795 2 1 1 0 0 0 7
XJ 26,545 1 1 0 1 (0.04) 1 (0.04) 0 20
XJ1§ 8,777 2 0 2 0 0 0 7
XJ2§ 7,374 0 0 0 0 0 0 6
CQ
 33,044
 0
 0
 0
0
 0
 0
 25
*Values are no. (no./1,000 live births) except as indicated. BJ, Tsinghua University Hospital; CQ, Chongqing Health Center for Women and Children; CS, Changsha Hospital for Maternal and Child Health; EOD, early-onset disease; GBS, group B Streptococcus; GD, Guangdong Women and Children’s Hospital; GX, The Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region; GZ, Guangzhou Women and Children’s Medical Center; HB, Hubei Maternal and Child Health Hospital; HY, The First Affiliated Hospital, Harbin Medical University; LOD, late-onset disease; NE, northeast; NJ, Nanjing Maternity and Child Health Care Hospital; NX, General Hospital of Ningxia Medical University; SH, Children’s Hospital of Fudan University; SY, Shengjing Hospital, China Medical University; TJ, Tianjin Central Hospital of Gynecology Obstetrics; TS, Tangshan Maternal and Child Health Care Hospital; XJ, Maternal and Child Health Care Hospital of Uygur Autonomous Region; XJ1, The First Affiliated Hospital of Xi’an Jiaotong University; XJ2, The Second Affiliated Hospital of Xi’an Jiaotong University; ZJ, Women’s Hospital, Zhejiang University. 
†Estimated using highest incidence of 0.76/1,000 live births reported from this study.
‡Maternal and child hospitals, except where indicated. One hospital, Children’s Hospital of Fudan University, participated in the study but is omitted from this table because it does not have an obstetrics department, it had no infants with GBS born in it, and it was not included in calculation of incidence rates.
§General hospital.

Main Article

Page created: October 15, 2019
Page updated: October 15, 2019
Page reviewed: October 15, 2019
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