Volume 25, Number 12—December 2019
Research
High Prevalence of Macrolide-Resistant Bordetella pertussis and ptxP1 Genotype, Mainland China, 2014–2016
Lijun Li1, Jikui Deng1, Xiang Ma1, Kai Zhou1, Qinghong Meng, Lin Yuan, Wei Shi, Qing Wang, Yue Li, and Kaihu Yao
Table 1
Clinical characteristics of 109 pertussis patients, Bejing Children’s Hospital, Beijing, China, October 2014–December 2016*
| Patient characteristic | No. (%) patients |
p value | ||
|---|---|---|---|---|
| Total patients, n = 109 | Fully vaccinated, n = 17 | Not vaccinated or undervaccinated, n = 92 | ||
| Fever | 28 (25.69) | 6 (35.29) | 22 (23.9) | 0.32 |
| Rhinorrhea | 47 (43.12) | 12 (70.59) | 35 (38.0) | 0.01 |
| Nasal congestion | 50 (45.87) | 8 (47.06) | 42 (45.65) | 0.92 |
| Purulent nasal secretion |
5 (4.59) |
1 (5.88) |
4 (4.35) |
1.00 |
| Cough | ||||
| Paroxysmal | 90 (82.57) | 13 (76.47) | 77 (83.70) | 0.71 |
| Spasmodic | 95 (87.16) | 13 (76.47) | 82 (89.13) | 0.30 |
| Whooping | 46 (42.20) | 9 (52.94) | 37 (40.22) | 0.33 |
| Excessive phlegm |
48 (44.04) |
5 (29.41) |
43 (46.74) |
0.19 |
| Vomiting | 66 (60.55) | 9 (52.94) | 57 (61.96) | 0.49 |
| Cyanosis | 72 (66.06) | 11 (64.71) | 64 (69.57) | 0.83 |
| Apnea | 27 (24.77) | 4 (23.53) | 20 (21.74) | 1.00 |
| Convulsion | 1 (0.92) | 0 | 1 (1.09) | 1.00 |
| Sweats | 25 (22.94) | 7 (41.18) | 18 (19.57) | 0.05 |
| Subconjunctival hemorrhage | 4 (3.67) | 0 (0.00) | 4 (4.35) | 0.50 |
| Ulcer of lingual frenum |
1 (0.92) |
0 |
1 (1.09) |
0.85 |
| Leukocytosis | ||||
| >10 × 109 cells/L | 74 (67.89) | 6 (35.29) | 68 (73.91) | <0.01 |
| >60 ×109 cells/L |
2 (1.89) |
0 |
0 |
NA |
| Lymphocytosis† |
73 (66.97) |
8 (47.06) |
65 (70.65) |
0.06 |
| Antimicrobial drugs prescribed before culture | ||||
| Erythromycin | 66 (60.55) | 7 (41.18) | 59 (31.52) | NA |
| Cephalosporin | 77 (70.64) | 11 (64.71) | 66 (71.74) | NA |
| Azithromycin | 16 (14.68) | 4 (23.53) | 13 (14.13) | NA |
| Amoxicillin | 8 (7.34) | 2 (11.76) | 6 (6.52) | NA |
| Clarithromycin | 2 (1.83) | 0 | 0 | NA |
| Mezlocillin | 1 (0.92) | 0 | 0 | NA |
| Imipenem | 1 (0.92) | 0 | 0 | NA |
| Aztreonam |
1 (0.92) |
0 |
0 |
NA |
| Household contacts | 52 (47.71) | 0 | 0 | NA |
| Culture-based diagnosis for household contacts‡ | 4 (3.67) | 0 | 0 | NA |
| Reexamination of culture§ | 4 (3.67) | 0 | 0 | NA |
*NA, not analyzed.
†Lymphocyte:total leukocyte ratio 66.47% ± 11.47%.
‡Bacterial culture results of the 4 household contacts were negative.
§Reexamination of bacterial culture of 4 patients performed 2 weeks later produced negative results.
1These authors contributed equally to this article.
Page created: November 18, 2019
Page updated: November 18, 2019
Page reviewed: November 18, 2019
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.