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Volume 25, Number 12—December 2019
Research

High Prevalence of Macrolide-Resistant Bordetella pertussis and ptxP1 Genotype, Mainland China, 2014–2016

Lijun Li1, Jikui Deng1, Xiang Ma1, Kai Zhou1, Qinghong Meng, Lin Yuan, Wei Shi, Qing Wang, Yue Li, and Kaihu YaoComments to Author 
Author affiliations: Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, Beijing, China (L. Li, Q. Meng, L. Yuan, W. Shi, Q. Wang, Y. Li, K. Yao); Shenzhen Children’s Hospital, Shenzhen, China (J. Deng); Jinan Children’s Hospital, Shandong University, Shandong, China (X. Ma); Nanjing Children’s Hospital, Nanjing Medical University, Nanjing, China

Main Article

Table 1

Clinical characteristics of 109 pertussis patients, Bejing Children’s Hospital, Beijing, China, October 2014–December 2016*

Patient characteristic No. (%) patients
p value
Total patients, n = 109 Fully vaccinated, n = 17 Not vaccinated or undervaccinated, n = 92
Fever 28 (25.69) 6 (35.29) 22 (23.9) 0.32
Rhinorrhea 47 (43.12) 12 (70.59) 35 (38.0) 0.01
Nasal congestion 50 (45.87) 8 (47.06) 42 (45.65) 0.92
Purulent nasal secretion
5 (4.59)
1 (5.88)
4 (4.35)
1.00
Cough
Paroxysmal 90 (82.57) 13 (76.47) 77 (83.70) 0.71
Spasmodic 95 (87.16) 13 (76.47) 82 (89.13) 0.30
Whooping 46 (42.20) 9 (52.94) 37 (40.22) 0.33
Excessive phlegm
48 (44.04)
5 (29.41)
43 (46.74)
0.19
Vomiting 66 (60.55) 9 (52.94) 57 (61.96) 0.49
Cyanosis 72 (66.06) 11 (64.71) 64 (69.57) 0.83
Apnea 27 (24.77) 4 (23.53) 20 (21.74) 1.00
Convulsion 1 (0.92) 0 1 (1.09) 1.00
Sweats 25 (22.94) 7 (41.18) 18 (19.57) 0.05
Subconjunctival hemorrhage 4 (3.67) 0 (0.00) 4 (4.35) 0.50
Ulcer of lingual frenum
1 (0.92)
0
1 (1.09)
0.85
Leukocytosis
>10 × 109 cells/L 74 (67.89) 6 (35.29) 68 (73.91) <0.01
>60 ×109 cells/L
2 (1.89)
0
0
NA
Lymphocytosis†
73 (66.97)
8 (47.06)
65 (70.65)
0.06
Antimicrobial drugs prescribed before culture
Erythromycin 66 (60.55) 7 (41.18) 59 (31.52) NA
Cephalosporin 77 (70.64) 11 (64.71) 66 (71.74) NA
Azithromycin 16 (14.68) 4 (23.53) 13 (14.13) NA
Amoxicillin 8 (7.34) 2 (11.76) 6 (6.52) NA
Clarithromycin 2 (1.83) 0 0 NA
Mezlocillin 1 (0.92) 0 0 NA
Imipenem 1 (0.92) 0 0 NA
   Aztreonam
1 (0.92)
0
0
NA
Household contacts 52 (47.71) 0 0 NA
Culture-based diagnosis for household contacts‡ 4 (3.67) 0 0 NA
Reexamination of culture§ 4 (3.67) 0 0 NA

*NA, not analyzed.
†Lymphocyte:total leukocyte ratio 66.47% ± 11.47%.
‡Bacterial culture results of the 4 household contacts were negative.
§Reexamination of bacterial culture of 4 patients performed 2 weeks later produced negative results.

Main Article

1These authors contributed equally to this article.

Page created: November 18, 2019
Page updated: November 18, 2019
Page reviewed: November 18, 2019
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