Volume 25, Number 2—February 2019
CME ACTIVITY - Synopsis
Zika Virus Epidemic in Pregnant Women, Dominican Republic, 2016–2017
Farah Peña, Raquel Pimentel, Shaveta Khosla, Supriya D. Mehta, and Maximo O. Brito
Table 1
Characteristics of pregnant women with suspected Zika virus infection, Dominican Republic, 2016–2017*
| Characteristic | No. (%) women, n = 1,282 | No. (%) PCR positive, n = 296 | No. (%) PCR negative, n = 406 | No. (%) not tested or sample discarded, n = 580 | p value† |
|---|---|---|---|---|---|
| Age, y | |||||
| >30 | 308 (24.0) | 60 (20.3) | 113 (27.8) | 135 (23.3) | 0.02 |
| <30 |
974 (76.0) |
236 (79.7) |
293 (72.2) |
445 (76.7) |
|
| Age distribution, y | |||||
| 12–19 | 201(15.7) | 45 (15.2) | 59 (14.5) | 97 (16.7) | 0.23 |
| 20–29 | 704 (54.9) | 173 (58.4) | 211 (52.0) | 320 (55.2) | |
| 30–39 | 357 (27.8) | 73 (24.7) | 126 (31.0) | 158 (27.2) | |
| >40 |
20 (1.6) |
5 (1.7) |
10 (2.5) |
5 (0.9) |
|
| Insurance status | |||||
| Yes | 762 (59.5) | 168 (56.8) | 225 (55.4) | 369 (63.6) | 0.83 |
| No | 362 (28.2) | 87 (29.4) | 118 (29.1) | 157 (27.1) | |
| Unknown |
158 (12.3) |
41 (13.8) |
63 (15.5) |
54 (9.3) |
|
| Region of residence | |||||
| Greater Santo Domingo‡ | 536 (41.8) | 106 (35.8) | 165 (40.6) | 265 (45.7) | 0.19 |
| Other |
746 (58.2) |
190 (64.2) |
241 (59.4) |
315 (54.3) |
|
| Country of origin | |||||
| Dominican Republic | 1273 (99.3) | 293 (99.0) | 402 (99.0) | 578 (99.7) | 1.00 |
| Haiti | 7 (0.5) | 2 (0.7) | 3 (0.7) | 2 (0.3) | |
| Other |
2 (0.2) |
1 (0.3) |
1 (0.3) |
||
| Care setting | |||||
| Ambulatory/at home |
1,098 (85.6) |
263 (88.8) |
349 (86.0) |
486 (83.8) |
0.26 |
| Hospital | 174 (13.6) | 33 (11.2) | 54 (13.3) | 87 (15.0) | |
| Unknown (includes referred) |
10 (0.8) |
0 |
3 (0.7) |
7 (1.2) |
|
| Complications | |||||
| None | 128 (10.0) | 24 (8.1) | 41 (10.1) | 63 (10.8) | 0.41 |
| Difficulty breathing | 3 (0.2) | 0 | 2 (0.5) | 1 (0.2) | |
| Unknown |
1151 (89.8) |
272 (91.9) |
363 (89.4) |
516 (89.0) |
|
| Diagnosis | |||||
| Confirmed | 296 (23.1) | ||||
| Suspected | 983 (76.9) | ||||
| Missing |
3 |
||||
| Time of suspected Zika infection | |||||
| ≤12 wk gestation | 364 (28.4) | 106 (35.8) | 152 (37.4) | 106 (18.3) | 0.66 |
| >12 wk gestation |
918 (71.6) |
190 (64.2) |
254 (62.6) |
474 (81.7) |
|
| Condition of newborn at birth | |||||
| IUFD/miscarriage | 70 (8.9) | 26 (13.1) | 22 (8.8) | 22 (6.5) | 0.15 |
| Live birth | 718 (91.1) | 173 (86.9) | 228 (91.2) | 317 (93.5) | |
| Missing |
494 |
97 |
156 |
241 |
|
| Premature birth, live born only, n = 718 | |||||
| Yes | 78 (10.9) | 21 (12.1) | 24 (10.5) | 33 (10.5) | 0.61 |
| No | 638 (89.1) | 152 (87.9) | 204 (89.5) | 282 (89.5) | |
| Missing |
2 |
2 |
|||
| Birthweight, live born only, n = 718 | |||||
| <2,500 g | 107 (15.4) | 27 (16.2) | 36 (16.6) | 44 (14.2) | 0.91 |
| ≥2,500 g | 588 (84.6) | 140 (83.8) | 181 (83.4) | 267 (85.8) | |
| Missing |
23 |
6 |
11 |
6 |
|
| Microcephaly§ | 3 | 0 | 1 | 2 | |
*IUFD, intrauterine fetal demise.
†χ2 p value for the comparison of confirmed PCR positive with PCR negative.
‡Includes residents of Monte Plata Province.
§Defined as head circumference <2 SD below the mean, adjusted for gestational age and sex, 24 h after birth.
Page created: January 17, 2019
Page updated: January 17, 2019
Page reviewed: January 17, 2019
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