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Volume 25, Number 2—February 2019
CME ACTIVITY - Synopsis

Zika Virus Epidemic in Pregnant Women, Dominican Republic, 2016–2017

Farah Peña, Raquel Pimentel, Shaveta Khosla, Supriya D. Mehta, and Maximo O. BritoComments to Author 
Author affiliations: Ministry of Health, Santo Domingo, Dominican Republic (F. Peña, R. Pimentel); University of Illinois at Chicago, Chicago, Illinois, USA (S. Khosla, S.D. Mehta, M.O. Brito)

Main Article

Table 3

Bivariate and multivariate analyses of independent variables with multinomial pregnancy outcome for women in Zika virus epidemic, Dominican Republic, 2016–2017*

Characteristic Birth outcome
p value by χ2 test Bivariate crude OR (95% CI)
Multivariate adjusted OR (95% CI), n = 786
Miscarriage or IUFD, n = 70 Premature live birth, n = 78 Term live birth, n = 638 Fetal loss vs. term live birth Premature vs. term live birth Fetal loss vs. term live birth Premature vs. term live birth
Maternal age, y
>30 24 (34.3) 20 (25.6) 162 (25.4) 0.27 1.53 (0.91–2.59) 1.01 (0.59–1.74) 1.48 (0.86–2.56) 1.02 (0.60–1.76)
<30
46 (65.7)
58 (74.4)
476 (74.6)
NA
NA
NA

NA
NA
Residence in Greater Santo Domingo†
Yes 27 (38.6) 39 (50.0) 262 (41.1) 0.27 0.90 (0.54–1.50) 1.44 (0.90–2.30) NA NA
No
43 (61.4)
39 (50.0)
376 (58.9)
NA
NA
NA

NA
NA
Diagnosis
Confirmed 26 (37.1) 21 (26.9) 152 (23.9) 0.05 1.88 (1.12–3.16) 1.18 (0.69–2.00) NA NA
Suspected
44 (62.9)
57 (73.1)
485 (76.1)
NA
NA
NA

NA
NA
Timing of suspected Zika infection, wks gestation
<12 46 (65.7) 22 (28.2) 156 (24.4) <0.0001 5.92 (3.50–10.0) 1.21 (0.72–2.05) 5.92 (3.49–10.0) 1.22 (0.72–2.07)
>12
24 (34.3)
56 (71.8)
482 (75.6)
NA
NA
NA

NA
NA
Symptoms‡
Rash 60 (85.7) 70 (89.7) 568 (89.0) 0.68 0.74 (0.36–1.51) 1.08 (0.50–2.33) NA NA
No rash 10 (14.3) 8 (10.3) 70 (11.0) NA NA NA NA NA
Fever 31 (44.3) 36 (46.2) 218 (34.2) 0.04 1.53 (0.93–2.52) 1.65 (1.03–2.65) 1.63 (0.97–2.75) 1.66 (1.03–2.66)
No fever 39 (55.7) 42 (53.8) 420 (65.8) NA NA NA NA NA

*IUFD, intrauterine fetal death; NA, not applicable; OR, odds ratio.
†Includes residents of Monte Plata Province.
‡No significant difference for other symptoms.

Main Article

Page created: January 17, 2019
Page updated: January 17, 2019
Page reviewed: January 17, 2019
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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