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Volume 25, Number 3—March 2019
CME ACTIVITY - Synopsis

Treatment Outcomes in Global Systematic Review and Patient Meta-Analysis of Children with Extensively Drug-Resistant Tuberculosis

Muhammad OsmanComments to Author , Elizabeth P. Harausz, Anthony J. Garcia-Prats, H. Simon Schaaf, Brittany K. Moore, Robert M. Hicks1, Jay Achar, Farhana Amanullah, Pennan Barry, Mercedes Becerra, Domnica I. Chiotan, Peter C. Drobac2, Jennifer Flood, Jennifer Furin, Medea Gegia, Petros Isaakidis, Andrei Mariandyshev, Iveta Ozere, N. Sarita Shah3, Alena Skrahina, Elena Yablokova, James A. Seddon4, Anneke C. Hesseling4, and for The Collaborative Group for Meta-Analysis of Paediatric Individual Patient Data in MDR TB
Author affiliations: Stellenbosch University, Cape Town, South Africa (M. Osman, A.J. Garcia-Prats, H.S. Schaaf, J.A. Seddon, A.C. Hesseling); State University of New York Upstate Medical University, Syracuse, New York, USA (E.P. Harausz); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (B.K. Moore); University of California, San Francisco, California, USA (R.M. Hicks); Médecins Sans Frontières, London, UK (J. Achar); Indus Hospital, Karachi, Pakistan (F. Amanullah); California Department of Public Health, Richmond, California, USA (P. Barry, J. Flood); Harvard Medical School, Boston, Massachusetts, USA (M. Becerra, P.C. Drobac, J. Furin); Romanian National TB Program, Bucharest, Romania (D.I. Chiotan); World Health Organization, Geneva, Switzerland (M. Gegia); Médecins Sans Frontières, Mumbai, India (P. Isaakidis); Northern State Medical University, Arkhangelsk, Russia (A. Mariandyshev, E. Yablokova); Riga Eastern Clinical University Hospital, Riga, Latvia (I. Ozere); Albert Einstein College of Medicine, Bronx, New York, USA (N.S. Shah); Republican Research and Practical Centre for Pulmonology and TB, Minsk, Belarus (A. Skrahina); Imperial College London, London (J.A. Seddon)

Main Article

Table 1

Overview of 14 studies and 37 children with confirmed cases of extensively drug-resistant tuberculosis*

Reference Country No. persons in study No. children with XDR TB Study design
Amanullah, unpub. data Pakistan 29 1 Retrospective cohort
Banerjee et al. (10) USA 18 1 Retrospective cohort
Chiotan, unpub. data Romania 17 1 Retrospective cohort
Drobac et al. (11) Peru 36 4 Retrospective cohort
Gegia et al. (12) Georgia 55 3 Retrospective cohort
Hicks et al. (13) South Africa 82 5 Retrospective cohort
Isaakidis et al. (14) India 8 2 Retrospective cohort
Kuksa et al. (15) Latvia 53 4 Retrospective cohort
Smirnova et al. (16) Russia 38 1 Retrospective cohort
Moore et al. (17) South Africa 339 5 Retrospective cohort
Seddon et al. (18) South Africa 88 5 Retrospective cohort
Seddon et al. (19) South Africa 131 2 Prospective cohort
Skrahina, unpub. data Belarus 5 2 Retrospective cohort
Swaminathan et al. (20) Tajikistan 27 1 Retrospective cohort

*Each study population involved all consecutively presenting bacteriologically confirmed and clinically diagnosed patients. XDR TB, extensively drug-resistant tuberculosis.

Main Article

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Main Article

1Current affiliation: University of California, San Francisco, California, USA.

2Current affiliation: Oxford University, Oxford, UK.

3Current affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

4These senior authors contributed equally to this article.

Page created: February 19, 2019
Page updated: February 19, 2019
Page reviewed: February 19, 2019
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