Volume 25, Number 3—March 2019
CME ACTIVITY - Synopsis
Treatment Outcomes in Global Systematic Review and Patient Meta-Analysis of Children with Extensively Drug-Resistant Tuberculosis
|Age, y, median 11 y (IQR 6.0–13.1 y)|
|5–9 y||6 (16)|
|10–14 y||22 (60)|
|Site of disease|
|PTB and EPTB‡||3 (8)|
|Severe TB disease by chest radiography, n = 31§|
|Documented adult TB source case, n = 28|
|Receiving treatment¶||7 (100)|
|Malnutrition, n = 30#|
|Admitted to hospital for TB treatment, n = 29|
|WHO TB treatment outcome|
|Loss to follow-up||2 (5)|
*EPTB, extrapulmonary tuberculosis; IQR, interquartile range; PTB, pulmonary tuberculosis; TB, tuberculosis; WHO, World Health Organization.
†Two cases of EPTB, 1 site specified as urogenital and 1 unspecified.
‡Three cases of PTB and EPTB. Sites of EPTB were peripheral lymph nodes and pleural TB in 1 child and abdominal TB in 2 children.
§Severity of TB based on grading of chest radiograph reports available only for 31 children; 2 children had EPTB only and no chest radiograph and 4 children had no chest radiograph despite documented PTB..
¶Six children were receiving antiretroviral therapy at the start of TB treatment and 1 child started antiretroviral therapy during the course of TB treatment.
#Underweight for age (weight-for-age z-score <–2) or as per treating clinician’s report.
**Includes all children who were cured or completed treatment.
††Includes all children who failed treatment, died, or were lost to follow-up during treatment.
1Current affiliation: University of California, San Francisco, California, USA.
2Current affiliation: Oxford University, Oxford, UK.
3Current affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
4These senior authors contributed equally to this article.