Genomic Analysis of Cardiac Surgery–Associated Mycobacterium chimaera Infections, United States
Nabeeh A. Hasan
, L. Elaine Epperson, Adrian Lawsin, Rachael R. Rodger, Kiran M. Perkins, Alison Laufer Halpin, K. Allison Perry, Heather Moulton-Meissner, Daniel J. Diekema, Matthew B. Crist, Joseph F. Perz, Max Salfinger, Charles L. Daley, and Michael Strong
Author affiliations: National Jewish Health, Denver, Colorado, USA (N.A. Hasan, L.E. Epperson, R.R. Rodger, M. Salfinger, C.L Daley, M. Strong); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (A. Lawsin, K.M. Perkins, A.L. Halpin, K.A. Perry, H. Moulton-Meissner, M.B. Crist, J.F. Perz); University of Iowa, Iowa City, Iowa, USA (D.J. Diekema)
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Figure 2
Figure 2. Maximum-likelihood phylogenetic relationships between HCU1 and US non-HCU–associated isolates (651 single-nucleotide polymorphisms [SNPs] in 4,024,718 core positions) as a circular phylogeny. From the center to the perimeter, colored circles indicate the country of origin, isolate source, and HCU genotype(s). Clinical isolate labels use country abbreviation: Australia (AUS), Denmark (DNK), Florence, Italy (FI), New Zealand (NZL), Switzerland (CHE), United Kingdom (GBR), United States (USA); HCU or PAT; isolate number. Non-HCU–associated isolates are from respiratory patients without a history of cardiac surgery. Suspected cases are isolates from blood or tissue samples collected from post–cardiac surgery patients; HCU are isolates collected from hospital HCUs (swabs, water, bioaerosols). Scale bar indicates SNPs. HCU, heater–cooler unit; PAT, suspected case-patient.
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