Volume 25, Number 3—March 2019
Dispatch
Genomic Analysis of Cardiac Surgery–Associated Mycobacterium chimaera Infections, United States
Nabeeh A. Hasan
, L. Elaine Epperson, Adrian Lawsin, Rachael R. Rodger, Kiran M. Perkins, Alison Laufer Halpin, K. Allison Perry, Heather Moulton-Meissner, Daniel J. Diekema, Matthew B. Crist, Joseph F. Perz, Max Salfinger, Charles L. Daley, and Michael Strong
, L. Elaine Epperson, Adrian Lawsin, Rachael R. Rodger, Kiran M. Perkins, Alison Laufer Halpin, K. Allison Perry, Heather Moulton-Meissner, Daniel J. Diekema, Matthew B. Crist, Joseph F. Perz, Max Salfinger, Charles L. Daley, and Michael Strong
Table
Mycobacteria chimaera isolated from HCUs, suspected patient case(s), and non–HCU-associated M. chimaera isolates in Australia, Europe, New Zealand, and the United States*
| Location | No. isolates | No. clinical | No. HCU | Status | Genotypes/location | No. HCU1 genotypes (%) | NCBI BioProject no. | Reference |
|---|---|---|---|---|---|---|---|---|
| Iowa 1 | 9 | 3 | 6 | HCU | 1 | 9 (100) | PRJNA345021 | (11); this study |
| Iowa 2 | 3 | 0 | 3 | HCU | 1 | 3 (100) | PRJNA345021 | This study |
| Kentucky | 1 | 0 | 1 | HCU | 1 | 1 (100) | PRJNA345021 | This study |
| Massachusetts 1 | 4 | 0 | 4 | HCU | 1 | 4 (100) | PRJNA345021 | This study |
| Michigan | 17 | 8 | 9 | HCU | 1 | 17 (100) | PRJNA345021 | This study |
| Minnesota | 1 | 1 | 0 | HCU | 1 | 1 (100) | PRJNA345021 | This study |
| Pennsylvania 1† | 25 | 10 | 15 | HCU | 2 | 23 (92) | PRJNA344472 | (11); this study |
| Virginia | 2 | 2 | 0 | HCU | 1 | 2 (100) | PRJNA345021 | This study |
| Australia 1 | 6 | 0 | 6 | HCU | 1 | 6 (100) | PRJEB15375 | (12) |
| Australia 2 | 13 | 1 | 12 | HCU | 3 | 11 (84.6) | PRJEB15375 | (12) |
| Australia 3 | 7 | 2 | 5 | HCU | 3 | 5 (71.4) | PRJEB15375 | (12) |
| Australia 4 | 10 | 2 | 8 | HCU | 2 | 9 (90) | PRJEB15375 | (12) |
| Denmark | 4 | 0 | 4 | HCU | 1 | 4 (100) | PRJEB18427 | (13) |
| New Zealand 1 | 2 | 0 | 2 | HCU | 1 | 2 (100) | PRJEB15375 | (12) |
| New Zealand 2 | 3 | 0 | 3 | HCU | 1 | 3 (100) | PRJEB15375 | (12) |
| New Zealand 3 | 5 | 0 | 5 | HCU | 1 | 5 (100) | PRJEB15375 | (12) |
| New Zealand 4 | 2 | 0 | 2 | HCU | 1 | 2 (100) | PRJEB15375 | (12) |
| United Kingdom | 3 | 0 | 3 | HCU | 1 | 3 (100) | PRJNA324238 | (13) |
| Zürich | 2 | 0 | 2 | HCU | 2 | 1 (50) | PRJNA313770, PRJNA314007 | (9) |
| Italy | 1 | 1 | 0 | Non-HCU | 1 | 0 | PRJEB18427 | (9) |
| Maryland | 1 | 1 | 0 | Non-HCU | 1 | 0 | PRJNA345021 | This study |
| Massachusetts 2 | 1 | 1 | 0 | Non-HCU | 1 | 0 | PRJNA319839 | This study |
| North Carolina | 1 | 1 | 0 | Non-HCU | 1 | 0 | PRJNA345021 | This study |
| Pennsylvania 2 | 1 | 1 | 0 | Non-HCU | 1 | 0 | PRJNA345021 | This study |
| Tennessee | 2 | 2 | 0 | Non-HCU | 1 | 0 | PRJNA319839 | This study |
| Texas | 2 | 2 | 0 | Non-HCU | 1 | 0 | PRJNA345021 | This study |
| Total | 38 | 90 | 112 (95)‡ |
*US isolates were collected during 2015–2016. Status refers to HCU-associated isolates (HCU) collected directly from Stöckert 3T Heater–Cooler Units (LivaNova PLC, https://www.livanova.com; formerly Sorin Group Deutschland GmbH) or from patients with suspected HCU-derived M. chimaera, and isolates from pulmonary NTM patients without history of HCU exposure (non-HCU). HCU, heater–cooler unit; NCBI, National Center for Biotechnology Information.
†Denotes the location from which the 2 samples (USA_PA_HCU_0, 2015–06–01; and USA_PA_PAT_10, 2015–22–65) did not pass the genomics quality control assessment and were excluded from the analyses.
‡Percentage was derived from the number of HCU1 genotype isolates in the number of isolates collected directly from LivaNova 3T HCU or suspected patient cases.
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