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Volume 25, Number 3—March 2019
Dispatch

Genomic Analysis of Cardiac Surgery–Associated Mycobacterium chimaera Infections, United States

Nabeeh A. HasanComments to Author , L. Elaine Epperson, Adrian Lawsin, Rachael R. Rodger, Kiran M. Perkins, Alison Laufer Halpin, K. Allison Perry, Heather Moulton-Meissner, Daniel J. Diekema, Matthew B. Crist, Joseph F. Perz, Max Salfinger, Charles L. Daley, and Michael Strong
Author affiliations: National Jewish Health, Denver, Colorado, USA (N.A. Hasan, L.E. Epperson, R.R. Rodger, M. Salfinger, C.L Daley, M. Strong); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (A. Lawsin, K.M. Perkins, A.L. Halpin, K.A. Perry, H. Moulton-Meissner, M.B. Crist, J.F. Perz); University of Iowa, Iowa City, Iowa, USA (D.J. Diekema)

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Table

Mycobacteria chimaera isolated from HCUs, suspected patient case(s), and non–HCU-associated M. chimaera isolates in Australia, Europe, New Zealand, and the United States*

Location No. isolates No. clinical No. HCU Status Genotypes/location No. HCU1 genotypes (%) NCBI BioProject no. Reference
Iowa 1 9 3 6 HCU 1 9 (100) PRJNA345021 (11); this study
Iowa 2 3 0 3 HCU 1 3 (100) PRJNA345021 This study
Kentucky 1 0 1 HCU 1 1 (100) PRJNA345021 This study
Massachusetts 1 4 0 4 HCU 1 4 (100) PRJNA345021 This study
Michigan 17 8 9 HCU 1 17 (100) PRJNA345021 This study
Minnesota 1 1 0 HCU 1 1 (100) PRJNA345021 This study
Pennsylvania 1† 25 10 15 HCU 2 23 (92) PRJNA344472 (11); this study
Virginia 2 2 0 HCU 1 2 (100) PRJNA345021 This study
Australia 1 6 0 6 HCU 1 6 (100) PRJEB15375 (12)
Australia 2 13 1 12 HCU 3 11 (84.6) PRJEB15375 (12)
Australia 3 7 2 5 HCU 3 5 (71.4) PRJEB15375 (12)
Australia 4 10 2 8 HCU 2 9 (90) PRJEB15375 (12)
Denmark 4 0 4 HCU 1 4 (100) PRJEB18427 (13)
New Zealand 1 2 0 2 HCU 1 2 (100) PRJEB15375 (12)
New Zealand 2 3 0 3 HCU 1 3 (100) PRJEB15375 (12)
New Zealand 3 5 0 5 HCU 1 5 (100) PRJEB15375 (12)
New Zealand 4 2 0 2 HCU 1 2 (100) PRJEB15375 (12)
United Kingdom 3 0 3 HCU 1 3 (100) PRJNA324238 (13)
Zürich 2 0 2 HCU 2 1 (50) PRJNA313770,
PRJNA314007 (9)
Italy 1 1 0 Non-HCU 1 0 PRJEB18427 (9)
Maryland 1 1 0 Non-HCU 1 0 PRJNA345021 This study
Massachusetts 2 1 1 0 Non-HCU 1 0 PRJNA319839 This study
North Carolina 1 1 0 Non-HCU 1 0 PRJNA345021 This study
Pennsylvania 2 1 1 0 Non-HCU 1 0 PRJNA345021 This study
Tennessee 2 2 0 Non-HCU 1 0 PRJNA319839 This study
Texas 2 2 0 Non-HCU 1 0 PRJNA345021 This study
Total 38 90 112 (95)‡

*US isolates were collected during 2015–2016. Status refers to HCU-associated isolates (HCU) collected directly from Stöckert 3T Heater–Cooler Units (LivaNova PLC, https://www.livanova.com; formerly Sorin Group Deutschland GmbH) or from patients with suspected HCU-derived M. chimaera, and isolates from pulmonary NTM patients without history of HCU exposure (non-HCU). HCU, heater–cooler unit; NCBI, National Center for Biotechnology Information.
†Denotes the location from which the 2 samples (USA_PA_HCU_0, 2015–06–01; and USA_PA_PAT_10, 2015–22–65) did not pass the genomics quality control assessment and were excluded from the analyses.
‡Percentage was derived from the number of HCU1 genotype isolates in the number of isolates collected directly from LivaNova 3T HCU or suspected patient cases.

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References
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  11. Perkins  KM, Lawsin  A, Hasan  NA, Strong  M, Halpin  AL, Rodger  RR, et al. Notes from the field: Mycobacterium chimaera contamination of heater-cooler devices used in cardiac surgery—United States. MMWR Morb Mortal Wkly Rep. 2016;65:11178. DOI
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Page created: February 19, 2019
Page updated: February 19, 2019
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