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Volume 25, Number 3—March 2019
Synopsis

Donor-Derived Genotype 4 Hepatitis E Virus Infection, Hong Kong, China, 2018

Siddharth Sridhar, Vincent C.C. Cheng, Shuk-Ching Wong, Cyril C.Y. Yip, Shusheng Wu, Anthony W.I. Lo, Kit-Hang Leung, Winger W.N. Mak, Jianpiao Cai, Xin Li, Jasper F.W. Chan, Susanna K.P. Lau, Patrick C.Y. Woo, Wai-Ming Lai, Tze-Hoi Kwan, Timmy W.K. Au, Chung-Mau Lo, Sally C.Y. Wong, and Kwok-Yung YuenComments to Author 
Author affiliations: The University of Hong Kong, Hong Kong, China (S. Sridhar, V.C.C. Cheng, S.-C. Wong, C.C.Y. Yip, S. Wu, K.-H. Leung, W.W.N. Mak, J. Cai, X. Li, J.F.W. Chan, S.K.P. Lau, P.C.Y. Woo, C.-M. Lo, S.C.Y. Wong, K.-Y. Yuen); Queen Mary Hospital, Hong Kong (A.W.I. Lo, T.W.K. Au); Princess Margaret Hospital, Hong Kong (W.-M. Lai); Tuen Mun Hospital, Hong Kong (T.-H. Kwan)

Main Article

Table 1

Characteristics of 5 patients who received organs from the same donor and had donor-derived genotype 4 hepatitis E virus infection, Hong Kong, China, 2018*

Case-patient 1 2 3 4 5
Organ transplanted Liver Lung Kidney Kidney Heart
Age, y/sex 66/M 59/M 6/M 54/F 48/F
Incubation period, d† 40 65 67 54 34
Signs/symptoms Ascites None None None None
Peak ALT level, U/L 1,385 138 490 186 130
Lymphocytes at hepatitis onset, × 109 cells/L 0.43 0.59 1.4 0.37 1.12
Pretransplantation HEV IgG‡ – + – – –
Pretransplantation HEV-IgG§ – – – – –
Posttransplantation HEV-IgM/HEV-IgG¶ +/+ +/+ −/− +/− −/−
Posttransplantation HEV-IgM/HEV-IgG§ +/+ +/+ −/− +/+ −/−

*All patients had received tacrolimus, mycophenolate, and prednisolone before onset of hepatitis E. ALT, alanine aminotransferase; HEV, hepatitis E virus.

†Time between transplantation and onset of abnormal ALT level.

‡HEV IgG ELISA (http://www.ystwt.cn/HEV.html).

§Western blot.

¶HEV IgM/HEV IgG ELISA (http://www.ystwt.cn/HEV.html).

Main Article

Page created: February 19, 2019
Page updated: February 19, 2019
Page reviewed: February 19, 2019
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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