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Volume 25, Number 3—March 2019
Synopsis

Donor-Derived Genotype 4 Hepatitis E Virus Infection, Hong Kong, China, 2018

Siddharth Sridhar, Vincent C.C. Cheng, Shuk-Ching Wong, Cyril C.Y. Yip, Shusheng Wu, Anthony W.I. Lo, Kit-Hang Leung, Winger W.N. Mak, Jianpiao Cai, Xin Li, Jasper F.W. Chan, Susanna K.P. Lau, Patrick C.Y. Woo, Wai-Ming Lai, Tze-Hoi Kwan, Timmy W.K. Au, Chung-Mau Lo, Sally C.Y. Wong, and Kwok-Yung YuenComments to Author 
Author affiliations: The University of Hong Kong, Hong Kong, China (S. Sridhar, V.C.C. Cheng, S.-C. Wong, C.C.Y. Yip, S. Wu, K.-H. Leung, W.W.N. Mak, J. Cai, X. Li, J.F.W. Chan, S.K.P. Lau, P.C.Y. Woo, C.-M. Lo, S.C.Y. Wong, K.-Y. Yuen); Queen Mary Hospital, Hong Kong (A.W.I. Lo, T.W.K. Au); Princess Margaret Hospital, Hong Kong (W.-M. Lai); Tuen Mun Hospital, Hong Kong (T.-H. Kwan)

Main Article

Table 2

Summary of studies describing HEV-4 infections in immunocompromised patients

Reference Patient age, y/sex Underlying immunosuppressive condition/treatment Peak ALT, U/L Progression to persistent HEV infection Ribavirin treatment/ response Patient outcome
(37)
 4/M
 Acute lymphoblastic leukemia
 585
 Spontaneous clearance, relapsed 20 mo later
 No
 Spontaneous clearance of relapse; resolution of hepatitis
(36)
 68/M
 Liver transplantation/tacrolimus
 149
 Yes
 Yes/yes
 Required retransplantation because of accelerated liver fibrosis; patient died of hemorrhage
(35)
 47/F
 Liver transplantation/tacrolimus
 Not reported
 Yes
 Yes/no
 Progressive cholestasis; patient died of sepsis
(11) 52/M Renal transplantation/prednisolone, cyclosporin A, and everolimus or sirolimus
 230 Yes Yes/no Ribavirin resistance; progressive cirrhosis
55/M 456 Yes Yes/yes Resolution of hepatitis
65/M
 470
 Yes
 Yes/yes
 Resolution of hepatitis
(38) 36/M Renal transplantation/ tacrolimus 300 Yes Yes/yes Relapse after ribavirin withheld; progressive hepatitis

*ALT, alanine aminotransferase; HEV, hepatitis E virus.

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Page updated: February 19, 2019
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