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Volume 25, Number 5—May 2019
Research

Formaldehyde and Glutaraldehyde Inactivation of Bacterial Tier 1 Select Agents in Tissues

Jennifer Chua1Comments to Author , Joel A. Bozue1, Christopher P. Klimko, Jennifer L. Shoe, Sara I. Ruiz, Christopher L. Jensen, Steven A. Tobery, Jared M. Crumpler, Donald J. Chabot, Avery V. Quirk, Melissa Hunter, David E. Harbourt, Arthur M. Friedlander, and Christopher K. CoteComments to Author 
Author affiliations: United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA

Main Article

Table 4

Routes of infection and delivered doses of Select Agents used to infect guinea pigs and rabbits for tissue collection in study of inactivation of bacterial Tier 1 Select Agents

Bacteria Route of infection Delivered dose, CFU Animal model Time of collection Tissue collected
Bacillus anthracis Ames (spores) Intradermal 2.7 × 108 Guinea pigs-Hartley 2 h after challenge Skin
Inhalational and/or intramuscular, respiratory 4.9 × 106 and
1.0 × 103 respiratory Guinea pigs-Strain 13 Late-stage disease Lung, liver, spleen

Inhalational
1.0 × 107
Rabbits-New Zealand White
24 h after challenge
Lung
Burkholderia pseudomallei 1026b
Intraperitoneal
9.0 × 102
Guinea pigs-Strain 13
Late-stage disease
Lung, liver, spleen
Francisella tularensis Schu S4
Subcutaneous
8.6 × 102
Guinea pigs-Strain 13
Late-stage disease
Lung, liver spleen
Yersina pestis CO92 Subcutaneous 7.0 × 104 Guinea pigs-Strain 13 Late-stage disease Lung, liver, spleen

Main Article

1These authors contributed equally to this article.

Page created: April 18, 2019
Page updated: April 18, 2019
Page reviewed: April 18, 2019
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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