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Volume 25, Number 5—May 2019
Dispatch

Fatal Meningitis in Patient with X-Linked Chronic Granulomatous Disease Caused by Virulent Granulibacter bethesdensis

Mafalda Rebelo1, Li Ding1, Ana Isabel Cordeiro, Conceição Neves, Maria João Simões, Adrian M. Zelazny, Steven M. Holland2, and João Farela Neves2Comments to Author 
Author affiliations: Hospital Dona Estefânia—Centro Hospitalar de Lisboa Central, Entidade Publica Empresarial, Lisbon, Portugal (M. Rebelo, A.I. Cordeiro, C. Neves, J.F. Neves); National Institute of Allergy and Infectious Diseases of the National Institutes of Health, Bethesda, Maryland, USA (L. Ding, A.M. Zelazny, S.M. Holland); National Institute of Health Dr. Ricardo Jorge, Lisbon (M.J. Simões); Chronic Diseases Research Center, NOVA Medical School, Lisbon (J.F. Neves)

Main Article

Figure 2

Granulibacter bethesdensis colonies and pathology results after inoculation on mouse models. A, B) CSF on chocolate agar for 4 days showed slowly growing brown-yellow, shiny colonies 2–4 mm in diameter. Full 16S RNA sequencing (≈1,500 bp) led to identification of G. bethesdensis (with 99.7% match). C) Survival of Gp91/p47 KO mice after inoculation of different G. bethesdensis strains. D) Pathology images of gp91KO mouse lung after CSF strain infection. E) Pathology images of gp91KO mouse lungs a

Figure 2. Granulibacter bethesdensis colonies and pathology results after inoculation on mouse models. A, B) CSF on chocolate agar for 4 days showed slowly growing brown-yellow, shiny colonies 2–4 mm in diameter. Full 16S RNA sequencing (≈1,500 bp) led to identification of G. bethesdensis (with 99.7% match). C) Survival of gp91/p47 KO mice after inoculation of different G. bethesdensis strains. D) Pathology images of gp91 KO mouse lung after CSF strain infection. E) Pathology images of gp91 KO mouse lungs after type strain infection. F) Quantification of G. bethesdensis strains in spleens of gp91/p47 KO mice after inoculation. CSF, cerebrospinal fluid; type, National Institutes of Health type strain; WT, wild type.

Main Article

1These authors contributed equally to this article.

2These authors contributed equally to this article.

Page created: April 18, 2019
Page updated: April 18, 2019
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