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Volume 25, Number 5—May 2019


Fatal Meningitis in Patient with X-Linked Chronic Granulomatous Disease Caused by Virulent Granulibacter bethesdensis

Mafalda Rebelo1, Li Ding1, Ana Isabel Cordeiro, Conceição Neves, Maria João Simões, Adrian M. Zelazny, Steven M. Holland2, and João Farela Neves2Comments to Author 
Author affiliations: Hospital Dona Estefânia—Centro Hospitalar de Lisboa Central, Entidade Publica Empresarial, Lisbon, Portugal (M. Rebelo, A.I. Cordeiro, C. Neves, J.F. Neves); National Institute of Allergy and Infectious Diseases of the National Institutes of Health, Bethesda, Maryland, USA (L. Ding, A.M. Zelazny, S.M. Holland); National Institute of Health Dr. Ricardo Jorge, Lisbon (M.J. Simões); Chronic Diseases Research Center, NOVA Medical School, Lisbon (J.F. Neves)

Main Article


Bacterial culture from blood and brain samples of GP91 KO mouse infected with Granulibacter bethesdensis after 4 weeks*

Mouse Strain Sample
Blood Brain
gp91−/−, n = 10 Type, USA 0 0
gp91−/−, n = 10 CSF, Portugal 5 2
p47−/−, n = 5 Type 0 0
p47−/−, n = 5 CSF 0 0
WT, n = 9 CSF, Portugal 0 ND

*Bold indicates the results of the inoculation of CSF strain in the gp91 KO mouse. CSF, cerebrospinal fluid; ND, not done; WT, wild type.

Main Article

1These authors contributed equally to this article.

2These authors contributed equally to this article.