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Volume 25, Number 6—June 2019
Dispatch

Pertactin-Negative and Filamentous Hemagglutinin-Negative Bordetella pertussis, Australia, 2013–2017

Zheng Xu, Sophie Octavia, Laurence Don Wai Luu, Michael Payne, Verlaine Timms, Chin Yen Tay, Anthony D. Keil, Vitali Sintchenko, Nicole Guiso, and Ruiting LanComments to Author 
Author affiliations: University of New South Wales, Sydney, New South Wales, Australia (Z. Xu, S. Octavia, L.D.W. Luu, M. Payne, R. Lan); New South Wales Health Pathology and Westmead Hospital, Sydney (V. Timms, V. Sintchenko); The University of Sydney, Sydney (V. Timms, V. Sintchenko); University of Western Australia, Perth, Western Australia, Australia (C.Y. Tay); Perth Children’s Hospital, Perth (A.D. Keil); Institut Pasteur, Paris, France (N. Guiso)

Main Article

Table

Mechanisms of pertactin deficiency and characteristics of Bordetella pertussis isolates from pertussis epidemics, Australia, 2013–2017*

Prn deficiency mechanism Position in prn† prn allele type State (no. of isolates) Year (no. isolates) References
IS481F 1613 prn2 Western Australia (32) 2013 (13) (1)
New South Wales (10) 2014 (5)
2015 (11)
2016 (9)
2017 (4)
IS481R 1613 prn2 Western Australia (12) 2013 (6) (1)
New South Wales (5) 2014 (5)
2015 (4)
IS481F 1598 prn3 Western Australia (3) 2013 (1) This study
2014 (2)
IS1002R 1613 prn2 Western Australia (4) 2013 (2) (1)
2016 (1)
2017 (1)
Deletion −297 to 1325 Not determined‡ Western Australia (2) 2014 (1) (8), newly found in Australia
2015 (1)
Stop codon
 223
 prn2
 Western Australia (1)
 2014 (1)
 (10), newly found in Australia
Deletion 2020–2023 prn2 Western Australia (1) 2013 (1) This study

*F/R denotes IS insertion orientation relative to prn. F, forward; IS, insertion sequence; Prn, pertactin; R, reverse.
†The nucleotide positions are relative to the initiation codon (ATG) of the prn in Tohama I.
‡prn allele type was not determinable because the repeat regions that define prn allele type was deleted in this mechanism.

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References
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Page updated: May 20, 2019
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