Volume 25, Number 6—June 2019
CME ACTIVITY - Synopsis
Nontuberculous Mycobacterial Musculoskeletal Infection Cases from a Tertiary Referral Center, Colorado, USA
Noah Goldstein1, J. Benjamin St. Clair1, Shannon H. Kasperbauer, Charles L. Daley, and Bennie Lindeque
Table 3
Microbiology and antimicrobial treatment of patients with nontuberculous mycobacterial musculoskeletal infections, Colorado, USA*
| Patient no. | Species | Oral therapy (duration, mo) | Intravenous therapy (duration, mo) | Total duration of therapy, mo | Time from last surgery to cessation of antimicrobial therapy, mo | Outcome |
|---|---|---|---|---|---|---|
| 1 | M. abscessus | Azithromycin (24) | Tigecycline + amikacin + imipenem (24) | 24 | 0 | Cured |
| 2 | M. abscessus | Azithromycin + linezolid (6) | Amikacin + imipenem (6) | 6 | 0 | Cured |
| 3 | M. abscessus | Azithromycin + clofazimine (20) | Imipenem + amikacin (15) | 20 | 0 | Cured |
| 4 | M. abscessus | Azithromycin + clofazimine (14) | Cefoxitin + amikacin (8) | 14 | 0 | Cured |
| 5 | M. fortuitum | Moxifloxacin (2) | Imipenem (2) | 2 | 1 | Cured |
| 6 | M. fortuitum | Doxycycline + ciprofloxacin + trimethoprim/ sulfamethoxazole (5) | Amikacin (3) | 5 | 3 | Cured |
| 7 | M. massiliense | Azithromycin, linezolid (4) | Cefoxitin, tigecycline, linezolid, amikacin, azithromycin (4) | 4† | NA | Treatment failure |
| 8 | M. intracellulare | Azithromycin + ethambutol + rifabutin (14) | Amikacin (8) | 14 | 1 | Cured |
| 9 | MAC, speciation unavailable | Azithromycin + clofazimine + ethambutol + rifampin (39) | Amikacin (2) | 39 | 11 | Cured |
| 10 | M. intracellulare | Azithromycin + rifampin + clofazimine + ethambutol (27) | Amikacin (5) | 27 | 7 | Cured |
| 11 | M. intracellulare | Azithromycin + moxifloxacin + ethambutol (9) | None | 9 | 5 | Cured |
| 12 | MAC, speciation unavailable | Azithromycin + ethambutol + rifampin (7) | None | 7 | 3 | Cured |
| 13 | M. gordonae | Azithromycin + trimethoprim/ sulfamethoxazole + ethambutol (16) | Amikacin (2) | 16 | 2 | Cured |
| 14 | M. marinum | Azithromycin + ciprofloxacin (14) | Imipenem (10) | 14 | 10 | Cured |
*All bacteria are Mycobacterium spp. MAC, Mycobacterium avium complex.
†Patient elected to discontinue antimicrobial treatment after experiencing intolerable side effects from multiple medications, despite ongoing disseminated infection.
1These first authors contributed equally to this article.
Page created: May 24, 2019
Page updated: May 24, 2019
Page reviewed: May 24, 2019
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