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Volume 25, Number 7—July 2019
Dispatch

Microbiome and Antimicrobial Resistance Gene Dynamics in International Travelers

Charles LangelierComments to Author , Michael Graves1, Katrina Kalantar1, Saharai Caldera, Robert Durrant, Mark Fisher, Richard Backman, Windy Tanner, Joseph L. DeRisi, and Daniel T. Leung
Author affiliations: University of California, San Francisco, California, USA (C. Langelier, K. Kalantar, S. Caldera, J.L. DeRisi); Chan Zuckerberg Biohub, San Francisco (C. Langelier, S. Caldera, J.L. DeRisi); University of Utah School of Medicine, Salt Lake City, Utah, USA (M. Graves, R. Durrant, M. Fisher, R. Backman, W. Tanner, D.T. Leung); ARUP Laboratories, Salt Lake City (R. Durrant, M. Fisher)

Main Article

Figure

Microbiome and AMR gene dynamics in international travelers. A) Longitudinal profile of traveler gut microbiome diversity measured by Shannon diversity Index. Traveler 5 (T5) had a Shannon diversity index >3 SDs below the mean when measured at 30 days and 6 months posttravel. B) Microbes, by genus, demonstrating the greatest fold change in abundance after travel on the basis of DNA sequencing nucleotide alignments. C) Total number of AMR genes identified with >20% allele coverage by DNA se

Figure. Microbiome and AMR gene dynamics in international travelers. A) Longitudinal profile of traveler gut microbiome diversity measured by Shannon diversity Index. Traveler 5 (T5) had a Shannon diversity index >3 SDs below the mean when measured at 30 days and 6 months posttravel. B) Microbes, by genus, demonstrating the greatest fold change in abundance after travel on the basis of DNA sequencing nucleotide alignments. C) Total number of AMR genes identified with >20% allele coverage by DNA sequencing. D) Total number of AMR genes identified with >20% allele coverage by RNA sequencing. AGLY, aminoglycoside; AMR, antimicrobial resistance; BLA, β-lactamase; FLQ, fluoroquinolone; MLS, macrolide, lincosamide, streptogramin; PRE, pretravel (within 1 week before departure); PST, posttravel (within 1 week after return); TMP/SUL, trimethoprim/sulfamethoxazole; TET, tetracycline; ESBL, extended-spectrum β-lactamase.

Main Article

1These authors contributed equally to this article.

Page created: June 17, 2019
Page updated: June 17, 2019
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