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Volume 25, Number 7—July 2019
Dispatch

Microbiome and Antimicrobial Resistance Gene Dynamics in International Travelers

Charles LangelierComments to Author , Michael Graves1, Katrina Kalantar1, Saharai Caldera, Robert Durrant, Mark Fisher, Richard Backman, Windy Tanner, Joseph L. DeRisi, and Daniel T. Leung
Author affiliations: University of California, San Francisco, California, USA (C. Langelier, K. Kalantar, S. Caldera, J.L. DeRisi); Chan Zuckerberg Biohub, San Francisco (C. Langelier, S. Caldera, J.L. DeRisi); University of Utah School of Medicine, Salt Lake City, Utah, USA (M. Graves, R. Durrant, M. Fisher, R. Backman, W. Tanner, D.T. Leung); ARUP Laboratories, Salt Lake City (R. Durrant, M. Fisher)

Main Article

Table 2

Fold change in abundance of AMR genes found in Enterobacteraciae with >20% allele coverage compared with pretravel, by resistance gene or drug class*

Resistance gene or drug class
 Fold change compared with pretravel
Posttravel
30 d
6 mo
DNA
 RNA
 DNA
 RNA
 DNA
 RNA
β-lactam AMR genes
AmpC >100 >100 >100 1 >100 2
AmpH >100 >100 >100 2 >100 1
CTX >100 >100 >100 >100 >100 >100
MrdA 50 >100 0 >100 5 >100
OXA 2 1 1 0 1 0
SHV >100 >100 >100 >100 >100 >100
TEM
 >100
 64
54
 0
15
 1
Other antibiotic classes
Aminoglycoside 2 3 1 0 0 0
Fluoroquinolone >100 >100 >100 >100 >100 >100
Glycopeptide 0 1 0 0 0 0
Macrolide, lincosamide, streptogramin 2 3 1 3 1 1
Sulfa 22 29 1 0 0 0
Tetracycline 1 1 1 0 1 0
Trimethoprim >100 88 >100 0 >100 1

*Among 10 participants who submitted samples pretravel (within 1 week before departure), posttravel (within 1 week after return), 30 days posttravel, and 6 month posttravel. AMR, antimicrobial resistance.

Main Article

1These authors contributed equally to this article.

Page created: June 17, 2019
Page updated: June 17, 2019
Page reviewed: June 17, 2019
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