Volume 25, Number 7—July 2019
Research
Nationwide Stepwise Emergence and Evolution of Multidrug-Resistant Campylobacter jejuni Sequence Type 5136, United Kingdom
, Norval J.C. Strachan, Meenakshi Ramjee, Anne Thomson, Marion MacRae, Sophie Shaw, and Ken J. Forbes
Table
Phenotypic evaluation of antimicrobial drug–resistant genotypes of Campylobacter jejuni ST5136 CC464 isolates, Scotland*
| pubMLST ID | Isolate | Year | Source | gyrA C257T | CIP | OXA† | AMP | tet variant‡ | TET | aac3 variant | KAN | TOB |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 38459 | ARI1530 | 2012 | Human stool | T | R | A | S | tet(O)80 | R | G1 | R | S |
| 39121 | ARI2250 | 2013 | Human stool | T | R | A | S | A | S | G1, G4 | R | S |
| 41320 | ARI3377 | 2014 | Human stool | T | R | OXA-465 | R | tet(O/32/O)7 | R | G1 | R | S |
| 40661 | ARI3044 | 2013 | Human stool | T | R | A | S | tet(O/M/O)218 | R | G1 | R | S |
| 38785 | ARI1899 | 2012 | Human stool | T | R | A | S | tet(O)13 | R | G1 | R | R |
| 38883 | ARI2002_1 | 2012 | Human stool | T | R | OXA-193 (G) | S | tet(O/32/O)7 | R | G1 | R | S |
| 39844 | C0525 | 2013 | Turkey | T | R | OXA-193 (T) | R | tet(O/32/O)7 | R | G1 | R | S |
| 42202 | C1204 | 2014 | Chicken | T | R | OXA-193 (T) | R | tet(O/32/O)7 | R | G1, G4 | R | R |
| 40371 | ARI2986 | 2013 | Human stool | T | R | OXA-193 (T) | R | tet(O/32/O)7 | R | G1, G4 | I | S |
| 48290 | ARI4158 | 2015 | Human stool | T | R | OXA-193 (T) | R | tet(O/32/O)7 | R | G1, G4 | I | S |
| 42443 | C1522 | 2015 | Chicken | T | R | OXA-193 (T) | R | tet(O/32/O)7 | R | G1, G4 | R | S |
| 58497 | C0112 | 2010 | Chicken | T | R | OXA-193 (T) | R | tet(O/32/O)7 | R | G1 | R | S |
| 58473 | ARI0533 | 2010 | Human stool | T | R | OXA-193 (T) | R | tet(O/32/O)7 | R | G1 | R | S |
| 41611 | C0972 | 2014 | Chicken | T | R | OXA-193 (T) | R | tet(O/32/O)7 | R | G2 | I | S |
| 39810 | C0469 | 2012 | Turkey | T | R | OXA-193 (T) | R | tet(O/32/O)7 | R | G1, G4 | R | S |
| 58159 | ARI3975 | 2015 | Human stool | C | S | OXA-193 (T) | R | tet(O/32/O)7 | R | G1, G4 | R | S |
| 39411 | ARI2623 | 2013 | Human stool | C | S | OXA-193 (T) | R | A | S | G1 | R | R |
| 38522 | ARI1599 | 2012 | Human stool | T | R | OXA-193 (T) | R | tet(O/32/O)7 | R | G1, G4 | R | R |
| 38475 | ARI1546 | 2012 | Human stool | T | R | A | S | tet(O/32/O)7 | R | G1 | R | R |
| 48369 | ARI3988 | 2015 | Human stool | T | R | A | S | tet(O/32/O)7 | R | G1 | R | S |
| 42114 | ARI3830 | 2015 | Human stool | C | S | OXA-193 (T) | R | tet(O/32/O)7 | R | G1, G4 | R | R |
| 48290 | ARI4158_20 | 2015 | Human stool | T | R | OXA-193 (T) | R | tet(O/32/O)7 | R | G1, G4 | I | S |
*Result based on disk susceptibility testing, except for ampicillin, for which MIC was estimated. R indicates MIC >128mg/L. All isolates were sensitive to amikacin, gentamicin, and streptomycin. aac3, 3-N-aminoglycoside acetyltransferase gene groups (G1–G4); AMP, ampicillin; CC, clonal complex; CIP, ciprofloxacin; I, intermediate; ID, identification; KAN, kanamycin; R, resistant; S, sensitive; ST, sequence type as determined by multilocus sequence typing; TET, tetracycline; TOB, tobramycin.
†OXA-465 = blaOXA-184-like gene; A indicates absence of oxacillinase gene; (G) or (T) indicates guanine or thymine mutation at −10 promoter of blaOXA-193.
‡A indicates absence of tetracycline resistance gene.