Volume 25, Number 8—August 2019
CME ACTIVITY - Synopsis
Zika Virus Infection in Pregnant Women, Yucatan, Mexico
Yamila Romer
, Nina Valadez-Gonzalez, Silvina Contreras-Capetillo, Pablo Manrique-Saide, Gonzalo Vazquez-Prokopec, and Norma Pavia-Ruz
, Nina Valadez-Gonzalez, Silvina Contreras-Capetillo, Pablo Manrique-Saide, Gonzalo Vazquez-Prokopec, and Norma Pavia-Ruz
Table 3
PCR results for Zika virus infection of clinical samples from pregnant women who showed development of infection during follow-up*
| Variable | No. (%) |
p value† | Odds ratio | ||
|---|---|---|---|---|---|
| Zika virus–positive, n = 36 | Zika virus–negative, n = 79 | Total, n = 115 | |||
| Age group, y | |||||
| 15–19 | 7 (19) | 19 (24) | 26 (23) | 0.639 | 0.76 |
| 20–29 | 20 (56) | 42 (53) | 62 (54) | 0.843 | 1.1 |
| 30–49 |
9 (25) |
18 (23) |
27 (23) |
0.815 |
1.13 |
| Socioeconomic level‡ | |||||
| 1 | 4 (11) | 3 (4) | 7 (6) | 0.12 | 3 |
| 2 | 13 (36) | 42 (53) | 55 (48) | 0.09 | 0.4 |
| 3 | 13 (36) | 24 (30) | 37 (32) | 0.54 | 1.2 |
| 4 |
6 (17) |
10 (13) |
16 (14) |
0.56 |
1.3 |
| Urban residency |
33 (92) |
70 (90) |
103 (90) |
0.78 |
1.25 |
| Contacts tested positive | |||||
| Family members | 3 (12) | 3 (5) | 7§ | 0.3 | 2.7 |
| Partner |
0 |
2 (3) |
2¶ |
1 |
1.4 |
| Working outside home |
18 (50) |
19 (24) |
37 (32) |
0.007 |
3.15 |
| GW at admission to cohort, trimester | |||||
| 5–13, first | 8 (22) | 22 (28) | 30 (26) | NA | NA |
| 14–27, second | 23 (64) | 39 (49) | 62 (53) | NA | NA |
| 28–40, third |
5 (14) |
18 (23) |
23 (20) |
NA |
NA |
| LMD/EW# | |||||
| 1–12 | 5 (15) | 22 (33) | 27 (27) | 0.093 | 0.373 |
| 13–28 | 15 (45) | 15 (22) | 30 (30) | 0.021 | 2.9 |
| 29–40 | 11 (33) | 11 (16) | 22 (22) | 0.07 | 2.6 |
| 41–52 | 2 (6) | 19 (28) | 21 (21) | 0.017 | 0.166 |
| 13–40/12–41 |
NA |
NA |
NA |
<0.0001 |
5.86 |
| Symptomatic | 23 (64) | 10 (13) | 33 (28) | <0.0001 | 12.2 |
| Exanthema | 23 (100) | 10 (100) | 33 (100) | <0.0001 | 12.2 |
| Conjunctival hyperemia | 17 (73) | 3 (30) | 20 (60) | <0.0001 | 22.6 |
| Arthralgia | 15 (65) | 3 (30) | 18 (55) | <0.0001 | 18.1 |
| Pruritus | 11 (48) | 0 | 11 (33) | <0.0001 | NA |
| Headache | 9 (39) | 2 (20) | 11 (33) | <0.0001 | 12.8 |
| Retro-orbital pain | 9 (39) | 0 | 9 (27) | <0.0001 | NA |
| Joint edema | 7 (30) | 1 (10) | 8 (24) | 0.001 | 18.8 |
| Myalgia | 6 (26) | 1 (10) | 7 (21) | 0.004 | 15.6 |
| Fever | 4 (17) | 1 (10) | 5 (15) | 0.033 | 9.7 |
| Diarrhea | 3 (13) | 0 | 3 (9) | 0.029 | NA |
| Odynophagia | 2 (9) | 0 | 2 (6) | 0.096 | NA |
| Cough | 2 (9) | 0 | 2 (6) | 0.096 | NA |
| Congested | 2 (9) | 0 | 2 (6) | 0.096 | NA |
| Nausea | 2 (9) | 1 (10) | 3 (9) | 0.230 | 4.5 |
| Vomiting | 1 (4) | 0 | 1 (3) | 0.313 | NA |
| Petechia | 1 (4) | 0 | 1 (3) | 0.313 | NA |
| Gingival bleeding | 1 (4) | 0 | 1 (3) | 0.313 | NA |
*Initial samples for all patients showed negative results. EW, epidemiologic week; GW, gestational week; LMD, last menstruation date; NA, not applicable; T, trimester.
†By Fisher exact test.
‡1, income insufficient to cover basic needs; 2, income just covers basic needs; 3, income for basic needs is met and includes certain recreational activities; 4, income is sufficient for recreational activities and luxuries.
§90 studied cases.
¶87 studied cases.
#>100 patients with LMD data.
Page created: July 15, 2019
Page updated: July 15, 2019
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