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Volume 25, Number 8—August 2019

Natural Vertical Transmission of Zika Virus in Larval Aedes aegypti Populations, Morelos, Mexico

Mónica Izquierdo-Suzán, Selene Zárate, Jesús Torres-Flores, Fabián Correa-Morales, Cassandra González-Acosta, Edgar E. Sevilla-Reyes, Rosalia Lira, Sofía L. Alcaraz-Estrada, and Martha Yocupicio-MonroyComments to Author 
Author affiliations: Universidad Autónoma de la Ciudad de Mexico, Mexico City, Mexico (M. Izquierdo-Suzán, S. Zárate, M. Yocupicio-Monroy); Instituto Politécnico Nacional, Mexico City (J. Torres-Flores); Centro Nacional de Programas Preventivos y Control de Enfermedades, Mexico City (F. Correa-Morales, C. González-Acosta); Instituto Nacional de Enfermedades Respiratorias, Mexico City (E.E. Sevilla-Reyes); Instituto Mexicano del Seguro Social, Mexico City (R. Lira); Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City (S.L. Alcaraz-Estrada)

Main Article

Table 2

Residue diversity between Zika virus isolate 31N from an Aedes aegypti larval pool and human- and mosquito-derived genomes, Jojutla, Morelos, Mexico*

Position Genome region Human-derived sequences
Mosquito-derived sequence
p value
SNVs, % Origin of minority variant
SNVs, % Origin of minority variant
1008 E T→C, 3.65 Mexico, United States, Thailand T→C, 17.64 31N, Mexico 0.000253
2071† NS1 C→T, 0.26 French Polynesia C→T, 2.94 31N 0.03
2871 NS2A T→C, 4.43 Mexico, United States T→C, 35.29 31N, Mexico, United States <0.0001
3176‡ NS2A CS A→C, 2.94 31N 0.01022
3286‡ NS2A CS A→G, 2.94 31N 0.01022
3333† NS2A A→G, 0.52 Mexico A→G, 2.94 31N >0.05
3788 NS2A C→T, 0.26 Brazil C→T, 8.82 31N, Mexico <0.0001
4500 NS2A A→G, 3.65 Mexico, United States, Philippines, South Korea A→G, 17.64 31N, Mexico 0.003847
4624 NS3 G→A, 3.39 United States, Mexico G→A, 17.64 31N, Mexico 0.002194
4980 NS3 T→C, 6.00 Mexico, Puerto Rico, Colombia, United States T→C, 17.64 31N, Mexico 0.01
5636‡ NS3 CS C→T, 2.94 31N 0.01022
7200 NS5 T→A 0.26; 
T→C, 3.91§ Mexico, USA, Suriname T→C, 17.64 31N, Mexico 0.006182
9139 NS5 C→T, 0.52 Mexico
C→T, 11.76 31N, Mexico <0.0001

*CS, conserved site in human-derived sequences; SNV, single nucleotide variant.
†SNVs in human-derived sequences but not in other mosquito genomes.
‡SNVs unique to the larva genome.
§Two SNVs located in the same genome position.

Main Article

Page created: July 16, 2019
Page updated: July 16, 2019
Page reviewed: July 16, 2019
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