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Volume 25, Number 8—August 2019
Dispatch

Evaluating Temperature Sensitivity of Vesicular Stomatitis Virus–Based Vaccines

Derek R. Stein, Patrycja Sroga, Bryce M. Warner, Yvon Deschambault, Guillaume Poliquin, and David SafronetzComments to Author 
Author affiliations: Public Health Agency of Canada, Winnipeg, Manitoba, Canada (D.R. Stein, Y. Deschambault, G. Poliquin, D. Safronetz); University of Manitoba, Winnipeg (P. Sroga, B.M. Warner, G. Poliquin, D. Safronetz)

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Figure 2

Evaluation of the effects of suboptimal storage of VSVΔG/LASVGPC in guinea pigs. A) Survival rates. B) Percentage weight loss. Values >100% indicate weight gain. C) Body temperatures. D) Viral titers. For A, B, and C, n = 6; for D, n = 3. Survival analysis was conducted using a log-rank Mantel-cox test. Viral loads in tissues were compared with VSVΔG/ANVDVGPC controls using a 2-way analysis of variance. *p<0.0001; †p = 0.002. Error bars indicate SEM.FT, freeze–thaw; RT, room temperature; T

Figure 2. Evaluation of the effects of suboptimal storage of VSVΔG/LASVGPC in guinea pigs. A) Survival rates. B) Percentage weight loss. Values >100% indicate weight gain. C) Body temperatures. D) Viral titers. For A, B, and C, n = 6; for D, n = 3. Survival analysis was conducted using a log-rank Mantel-cox test. Viral loads in tissues were compared with VSVΔG/ANVDVGPC controls using a 2-way analysis of variance. *p<0.0001; †p = 0.002. Error bars indicate SEM.FT, freeze–thaw; RT, room temperature; TCID50, 50% tissue culture infectious dose; VSVΔG/ANDVGPC, vesicular stomatitis virus–based Andes virus vaccine; VSVΔG/LASVGPC, vesicular stomatitis virus–based Lassa virus vaccine.

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Page created: July 17, 2019
Page updated: July 17, 2019
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