Volume 25, Number 8—August 2019
Evaluating Temperature Sensitivity of Vesicular Stomatitis Virus–Based Vaccines
|VSVΔG/LASVGPC||Stock vaccine||1.29 × 106||†||83|
|3× freeze–thaw||7.43 × 105||1.74||100|
|4°C for 7 d||1.05 × 106||1.23||83|
|Room temperature for 7 d||2.86 × 105||4.51||83|
|32°C for 7 d||3.75 × 104||34.40||66|
*VSVΔG/EBOVGPC, vesicular stomatitis virus–based Ebola virus vaccine; VSVΔG/LASVGPC, vesicular stomatitis virus–based Lassa virus vaccine.
†Stock vaccine was not subject to any treatments and thus had no -fold change. The fold change for all other treatment groups was calculated on the basis of the original dose of stock vaccine.