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Volume 26, Number 1—January 2020
Dispatch

Varicella in Adult Foreigners at a Referral Hospital, Central Tokyo, Japan, 2012–2016

Saho Takaya, Satoshi KutsunaComments to Author , Yuichi Katanami, Kei Yamamoto, Nozomi Takeshita, Kayoko Hayakawa, Yasuyuki Kato, Shuzo Kanagawa, and Norio Ohmagari
Author affiliations: National Center for Global Health and Medicine, Tokyo, Japan

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Abstract

We report a case series of varicella among adult foreigners at a referral hospital in central Tokyo, Japan, during 2012–2016. This series highlights differences in varicella vaccination schedules by country and epidemiology by climate and identifies immigrants and international students as high-risk populations for varicella.

Varicella is a benign disease with fever and rash caused by primary infection with varicella zoster virus (VZV) (1). Varicella is usually self-limiting but can sometimes be life-threatening, especially in adults (1). The World Health Organization estimates that 140 million varicella cases and 4,200 related deaths occur each year (1). In Japan, 1 million persons, primarily young children, have varicella every year. Of these patients, 4,000 require hospitalization, and adults make up ≈60% of this population (2).

Varicella vaccine is a live attenuated vaccine and is effective against varicella in healthy children (1). One dose of varicella vaccine reduces the number of varicella cases but can also reduce opportunities for exposure to the virus in the community and result in breakthrough varicella. Therefore, many industrialized countries now recommend 2 doses of varicella vaccine (2). In Japan, the 2-dose varicella vaccination became part of the childhood immunization schedule in October 2014; the number of varicella cases has drastically decreased since implementation (3).

We report cases of varicella in adult foreigners who were given a diagnosis at the National Center for Global Health and Medicine (NCGM) Medical Center in central Tokyo, Japan. These cases highlight major health issues, including differences in varicella vaccination programs in countries and VZV epidemiology in temperate and tropical regions, and identify immigrants and international students as high-risk populations for varicella.

The Study

We reviewed 22 varicella cases in adult foreigners diagnosed during January 2012–December 2016 at the NCGM. During the same period, 7 cases of varicella were diagnosed in Japanese adults at the NCGM. We compiled basic demographic information for the patients (Table). Eleven case-patients were from Vietnam, 5 from China, and 1 each from 6 other countries (Cambodia, New Zealand, Belgium, Italy, Uzbekistan, and Nepal). Among 21 patients who resided in central Tokyo, 18 were international students. Fourteen patients were male, and the median age was 19 years (range 18–35 years).

The patients sought medical care on median day 2 of illness (range days 1–5). Most diagnoses of varicella were made clinically; for some case-patients, varicella was confirmed by serologic testing or PCR or antigen detection testing of skin lesions. Twenty patients received antiviral therapy (acyclovir or valacyclovir). Five case-patients were hospitalized because of severe malaise and for infection control to prevent secondary cases.

Nine patients from Vietnam and 1 from China (case-patients 3–12) were students at the same language school who lived together in the school dormitories. During this outbreak, varicella developed in 9 students during a 2-month period after the index case (case 3). Information about previous vaccination and past infection could not be obtained for most patients in this outbreak because of their inability to communicate in Japanese or English and our inability to organize translation in the first language of the patients immediately at their visits. Overall, we found that there were 81 international students in 3 dormitories: 30 (37.0%) reported previous varicella and 6 (7.4%) claimed to have been vaccinated at least once. Although we contacted the school to provide postexposure prophylaxis, none of 41 students without previous VZV infection had received it.

Conclusions

Japan has >2 million foreign residents; most are from China (30%), South Korea (20%), and the Philippines (10%) (4). However, Japan does not have any vaccination requirements for foreign residents. Because varicella is not a target of the World Health Organization Expanded Program on Immunization, the vaccine is not included in the national immunization schedules of many countries.

In China, from which Japan receives most of its immigrants and tourists, varicella vaccine was approved in the late 1990s and has been given on a voluntary basis (5). Although 80% of children in kindergartens and primary schools in Beijing were reported to have received the varicella vaccine, most had only received 1 dose, and breakthrough varicella has become a public health concern (5). In South Korea, the single-dose varicella vaccination was included in the national immunization program in 2005 and is recommended for 12–15-month-old children (6). Despite high use of the vaccine (>95%), varicella outbreaks continuously occur (6). The varicella vaccine has not been introduced into the national vaccination program of the Philippines (7).

The epidemiology of varicella differs between temperate and tropical regions. In temperate areas, most of the population contracts VZV before adolescence. In tropical areas, childhood varicella is much less common, and many persons stay susceptible to VZV until adulthood (1,8). This difference is attributed to changes in VZV transmissibility by temperature and humidity, population density, and sociologic factors, such as nursery school attendance (8).

Previous research has shown immigrants and refugees to be at high risk for varicella. A study in Denmark during the 1980s investigated an epidemic of varicella among refugees during a preasylum phase (9). The study showed that 44% of Tamil refugees from Sri Lanka had varicella infections within 1 week to 5 months after arrival in Denmark. Considering that many immigrants contracted varicella shortly after their arrival, it was deemed necessary to check VZV immunity for immigrants before they entered that country, rather than after entry.

In an outbreak study of 18 varicella cases among Mexican-born workers in Alabama, USA (10), Mexican-born workers were 5 times more likely to be susceptible to VZV than US-born workers. Although postexposure prophylaxis vaccine was provided to susceptible workers, a second dose was not administered to many of those who needed it. This finding shows the difficulty in reaching these populations because of their lack of stable access to healthcare. Faced with a rapidly aging population, Japan has also been accepting nurses and caregivers from countries in Southeast Asia as medical personnel in healthcare facilities and nursing homes (11). Thus, nosocomial infection with VZV is also a matter of concern.

Japan had 208,000 international students during 2015 (12). More than 90% of these students were from countries in Asia; most were from China (45%), Vietnam (19%), and Nepal (8%). The demographics of the case-patients in our study were consistent with these data. In general, colleges are suitable environments for communicable disease outbreaks because of highly dense interactions among students and staff, crowded living conditions, and an influx of students from many countries (13). Because 10%–20% of persons in Japan 15–30 years of age are susceptible to VZV (14), varicella outbreaks among international students might spread into the local student population. Despite these facts, Japan does not have any regulations or recommendations regarding the health of international students. In the United States, the American College Health Association strongly recommends institutional prematriculation immunizations (15). These guidelines recommend that all college students should have 2 doses of varicella vaccine unless they have other evidence of VZV immunity.

This varicella case series occurred in multifactorial contexts. However, little is known about the immunity against VZV among foreign residents in Japan. Educational institutions that receive international students need to consider varicella as a major preventable health issue among their students. Healthcare providers for immigrants and international students should also be aware of the risk for varicella and should verify VZV immunity or varicella vaccination status for students.

Dr. Takaya is a physician at the Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan. Her primary research interest is tropical medicine.

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Acknowledgment

This study was supported by a grant (27-6001) from the National Center for Global Health and Medicine, Tokyo, Japan.

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References

  1. World Health Organization. Varicella and herpes zoster vaccines: WHO position paper; 2014 [cited 2016 Jun 2]. http://www.who.int/immunization/position_papers/WHO_pp_varicella_herpes_zoster_june2014_presentation.pdf
  2. National Institute of Infectious Diseases. Japan. Varicella vaccine fact sheet; 2010 [cited 2016 Nov 4]. http://www.mhlw.go.jp/stf2/shingi2/2r9852000000bx23-att/2r9852000000bxqx.pdf
  3. National Institute of Infectious Diseases. Japan. Varicella situation update after the introduction of two doses of varicella vaccine into the routine vaccination, from Infectious Diseases Weekly Report (IDWR), a third report [cited 2018 Apr 20]. https://www.niid.go.jp/niid/ja/varicella-m/varicella-idwrs/7620-varicella-20171020.html
  4. Japanese Ministry of Justice. The number of foreign residents in Japan as of December 2015–2016 [cited 2016 Dec 7]. http://www.moj.go.jp/nyuukokukanri/kouhou/nyuukokukanri04_00057.html
  5. Zhang  X, Yu  Y, Zhang  J, Huang  S, Wang  Z, Zhang  J, et al. The epidemiology of varicella cases among children in Beijing’s Fengtai District from 2008 to 2012. Vaccine. 2014;32:356972. DOIPubMed
  6. Oh  SH, Choi  EH, Shin  SH, Kim  YK, Chang  JK, Choi  KM, et al. Varicella and varicella vaccination in South Korea. Clin Vaccine Immunol. 2014;21:7628. DOIPubMed
  7. World Health Organization. WHO vaccine-preventable diseases: monitoring system; 2017 global summary [cited 2018 Apr 20]. http://apps.who.int/immunization_monitoring/globalsummary
  8. Lolekha  S, Tanthiphabha  W, Sornchai  P, Kosuwan  P, Sutra  S, Warachit  B, et al. Effect of climatic factors and population density on varicella zoster virus epidemiology within a tropical country. Am J Trop Med Hyg. 2001;64:1316. DOIPubMed
  9. Kjersem  H, Jepsen  S. Varicella among immigrants from the tropics, a health problem. Scand J Soc Med. 1990;18:1714. DOIPubMed
  10. Danovaro-Holliday  MC, Gordon  ER, Jumaan  AO, Woernle  C, Judy  RH, Schmid  DS, et al. High rate of varicella complications among Mexican-born adults in Alabama. Clin Infect Dis. 2004;39:16339. DOIPubMed
  11. Ministry of Health, Labour, and Welfare. Acceptance of foreign nurses and carers from Indonesia, the Philippines, and Vietnam [cited 2016 Dec 5]. http://www.mhlw.go.jp/stf/seisakunitsuite/bunya/koyou_roudou/koyou/gaikokujin/other22/index
  12. Japan Student Services Organization. International students in Japan; 2015 [cited 2016 Nov 5]. http://www.jasso.go.jp/en/about/statistics/intl_student/data2015.html
  13. Jewett  A, Bell  T, Cohen  NJ, Buckley  K, Leino  EV, Even  S, et al. US college and university student health screening requirements for tuberculosis and vaccine-preventable diseases, 2012. J Am Coll Health. 2016;64:40915. DOIPubMed
  14. National Institute of Infectious Diseases. Japan. Immunity status for varicella-zoster virus between 2014 and 2016 [cited 2018 Apr 20]. https://www.niid.go.jp/niid/ja/y-graphs/7200-varicella-yosoku-year2016.html
  15. American College Health Association. ACHA guidelines: recommendations for institutional prematriculation immunizations; 2014 [cited 2018 Apr 20]. https://www.acha.org/documents/resources/guidelines/ACHA_RIPI_April_2014.pdf

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Table

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Cite This Article

DOI: 10.3201/eid2601.170565

Original Publication Date: December 11, 2019

Table of Contents – Volume 26, Number 1—January 2020

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Satoshi Kutsuna, Disease Control and Prevention Center, National Center for Global Health and Medicine, 1-21-1, Toyama, Shinjuku, Tokyo 162-8655, Japan

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Page created: December 17, 2019
Page updated: December 17, 2019
Page reviewed: December 17, 2019
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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