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Volume 26, Number 10—October 2020

Effectiveness of 23-Valent Pneumococcal Polysaccharide Vaccine against Invasive Pneumococcal Disease in Adults, Japan, 2013–2017

Reiko Shimbashi, Motoi SuzukiComments to Author , Bin Chang, Hiroshi Watanabe, Yoshinari Tanabe, Koji Kuronuma, Kengo Oshima, Takaya Maruyama, Hiroaki Takeda, Kei Kasahara, Jiro Fujita, Junichiro Nishi, Tetsuya Kubota, Keiko Tanaka-Taya, Tamano Matsui, Tomimasa Sunagawa, Kazunori Oishi, and Adult IPD Study Group
Author affiliations: National Institute of Infectious Diseases, Tokyo, Japan (R. Shimbashi, M. Suzuki, B. Chang, K. Tanaka-Taya, T. Matsui, T. Sunagawa, K. Oishi); Tohoku University Graduate School of Medicine, Miyagi, Japan (R. Shimbashi, M. Suzuki, K. Oshima); Kurume University School of Medicine, Fukuoka, Japan (H. Watanabe); Niigata Prefectural Shibata Hospital, Niigata, Japan (Y. Tanabe); Sapporo Medical University School of Medicine, Hokkaido, Japan (K. Kuronuma); National Hospital Organization Mie National Hospital, Mie, Japan (T. Maruyama); Yamagata Saisei Hospital, Yamagata, Japan (H. Takeda); Nara Medical University, Nara, Japan (K. Kasahara); Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (J. Fujita); Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan (J. Nishi); Kochi Medical School, Kochi University, Kochi, Japan (T. Kubota); Toyama Institute of Health, Toyama, Japan (K. Oishi)

Main Article

Table 3

Effectiveness of PPSV23 against invasive pneumococcal disease in adults >20 years of age, by age group and study period, Japan, 2013–2017*

Age group, y   Adjusted VE,† % (95% CI)
  p value by test for interaction
2013–2015 2016–2017
Overall 47.1 (−4.7 to 73.3) 39.3 (−2.9 to 64.2) 0.953
20–64 77.1 (−110.4 to 97.5) 41.0 (−128.8 to 84.8) 0.124
>65 39.9 (−28.4 to 71.9) 39.4 (−6.1 to 65.3) 0.809

*BMI, body mass index; PPSV23, 23-valent pneumococcal polysaccharide vaccine; VE, vaccine effectiveness.
†Adjusted for sex, age, prefecture, year, season, BMI group, underlying conditions, and smoking history with clustering by public health center.

Main Article

Page created: August 05, 2020
Page updated: September 17, 2020
Page reviewed: September 17, 2020
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