Volume 26, Number 10—October 2020
Research
Association between Shiga Toxin–Producing Escherichia coli O157:H7 stx Gene Subtype and Disease Severity, England, 2009–2019
Lisa Byrne
, Natalie Adams, and Claire Jenkins
, Natalie Adams, and Claire Jenkins
Table 2
Disease severity of 3,225 clinical cases of Shiga toxin–producing Escherichia coli O157:H7 Stx subtype infection, by isolate Stx subtype and sublineage, England, 2009–2019
| Lineage, stx profile | All cases, no. (%) | Mild illness, no. (%)* | Severe illness, no. (%)† |
|---|---|---|---|
| Ic | |||
| stx2c stx1a | 2 (0.3) | 0 | 2 (100) |
| stx2c | 15 (1.9) | 9 (60) | 6 (40) |
| stx2a | 309 (39.2) | 97 (31.4) | 212 (68.6) |
| stx2a stx2c | 455 (57,7) | 129 (28.4) | 326 (71.6) |
| stx1a | 1 (0.1) | 0 | 1 (100) |
| stx2a stx1a | 7 (0.9) | 0 | 7 (100) |
| stx2a stx2c stx1a |
0 |
0 |
0 |
| I/II | |||
| stx2c stx1a | 0 | 0 | 0 |
| stx2c | 1 (0.8) | 0 | 1 (100) |
| stx2a | 82 (61.7) | 9 (11) | 73 (89) |
| stx2a stx2c | 50 (37.6) | 14 (28) | 36 (72) |
| stx1a | 0 | 0 | 0 |
| stx2a stx1a | 0 | 0 | 0 |
| stx2a stx2c stx1a |
0 |
0 |
0 |
| IIb | |||
| stx2c stx1a | 5 (1.5) | 2 (40) | 3 (60) |
| stx2c | 60 (17) | 47 (78.3) | 13 (21.7) |
| stx2a | 257 (76.5) | 134 (52.1) | 123 (47.9) |
| stx2a stx2c | 14 (4.2) | 4 (28.6) | 10 (71.4) |
| stx1a | 0 | 0 | 0 |
| stx2a stx1a | 0 | 0 | 0 |
| stx2a stx2c stx1a |
0 |
0 |
0 |
| Other | |||
| stx2c stx1a | 896 (7.8) | 284 (41.9) | 612 (58.1) |
| stx2c | 599 (67.4) | 479 (80.1) | 120 (19.9) |
| stx2a | 38 (3.4) | 14 (21.1) | 24 (78.9) |
| stx2a stx2c | 310 (14.9) | 93 (37.8) | 217 (62.2) |
| stx1a | 31 (1.6) | 13 (66.7) | 18 (33.3) |
| stx2a stx1a | 44 (4.5) | 9 (20) | 35 (80) |
| stx2a stx2c stx1a | 49 (0.4) | 9 (0) | 40 (0) |
*Asymptomatic or nonbloody diarrhea.
†Bloody diarrhea, hemolytic uremic syndrome, or death.
Page created: July 29, 2020
Page updated: September 17, 2020
Page reviewed: September 17, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.