Volume 26, Number 10—October 2020
Research Letter
Disappearance of SARS-CoV-2 Antibodies in Infants Born to Women with COVID-19, Wuhan, China
Table
Sequential severe acute respiratory syndrome coronavirus 2–specific antibodies assay in 24 infants born to mothers with PCR-confirmed coronavirus disease, Wuhan, China, January 19–April 12, 2020*
Case no. |
GA, wk+d |
||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
At symptom onset | At birth | ||||||||||
IgM/IgG titers, AU/mL, by age of infant |
|||||||||||
0 d | 7 d | 14 d | 28 d | 45 d | 60 d | 75 d | |||||
1 |
Mother | 7.5/116.9* | 33+4 |
36+3 |
|||||||
Infant |
0.8/0.3 |
||||||||||
2 |
Mother | 4.4/118.3 | 38+5 |
38+5 |
|||||||
Infant |
0.5/2.5 |
||||||||||
3 |
Mother | 5.0/83.3 | 37+5 |
38+2 |
|||||||
Infant |
0.4/0.2 |
||||||||||
4 |
Mother | 14.5/100.8 | 39+1 |
39+5 |
|||||||
Infant |
0.3/0.3 |
||||||||||
5 |
Mother | 34 |
35+2 |
||||||||
Infant |
0.7/2.8 |
0.4/3.5 |
0.3/0.9 |
||||||||
6 |
Mother | 7.0/93.0 | 39+3 |
40 |
|||||||
Infant |
0.4/0.3 |
||||||||||
7 |
Mother | 51.1/94.6 | 39+4 |
41+2 |
|||||||
Infant |
0.3/0.9 |
||||||||||
8 |
Mother | 67.0/92.6 | 37+4 |
38+4 |
|||||||
Infant |
0.3/0.1 |
||||||||||
9 |
Mother | 17.8/104.3 | 38+2 |
39+5 |
|||||||
Infant |
0.4/8.2 |
||||||||||
10 |
Mother | 15.3/95.4 | 9.9/108.7 | 38+1 |
39+5 |
||||||
Infant |
2.2/32.7 |
0.7/19.5 |
|||||||||
11 |
Mother | 11.3/112.5 | 5.3/105.6 | 35+5 |
38+2 |
||||||
Infant |
3.6/166.0 |
5.3/120.8 |
1.0/36.2 |
0.4/16.2 |
|||||||
12 |
Mother | +/+† | 37.9/94.6 | 29+4 |
31 |
||||||
Infant |
5.7/142.0 |
2.6/113.9 |
1.8/75.3 |
0.3/22.0 |
0.4/11.3 |
||||||
13 |
Mother | +/+ | 34+3 |
38 |
|||||||
Infant |
3.5/134.1 |
2.4/125.0 |
2.8/119.0 |
0.7/24.6 |
|||||||
14 |
Mother | 7.0/61.1 | 1.9/59.5 | 34+6 |
39 |
||||||
Infant |
2.2/78.4 |
1.5/76.9 |
3.0/80.9 |
0.8/28.6 |
0.5/13.0 |
||||||
15 |
Mother | 0.7/58.9 | NA |
37+2 |
|||||||
Infant |
8.5/174.5 |
7.8/122.7 |
|||||||||
16 |
Mother | +/+ | NA |
38+3 |
|||||||
Infant |
0.7/101.0 |
||||||||||
17 |
Mother | +/+ | 1.5/104.2 | NA |
38+3 |
||||||
Infant |
1.2/110.4 |
10.4/108.9 |
2.1/68.2 |
||||||||
18 |
Mother | –/+ | 4.8/54.5 | NA |
39+5 |
||||||
Infant |
6.6/96.2 |
11.3/86.0 |
11.9/88.3 |
2.5/60.9 |
|||||||
19 |
Mother | 2,581.6/281 | 40.2/89.8 | 13.9/99.6 | 6.9/94.2 | 32+1 |
38 |
||||
Infant |
184.3/147.2 |
42.6/161.6 |
21.2/83.8 |
5.5/79.2 |
1.6/57.0 |
0.3/25.9 |
|||||
20 |
Mother | 6.9/82.8 | 6.0/81.3 | 31+1 |
39+5 |
||||||
Infant |
25.7/68.8 |
3.0/58.4 |
0.4/47.4 |
||||||||
21 |
Mother | +/+ | 5.1/139.0 | 30+3 |
38 |
||||||
Infant |
26.0/145.8 |
41.8/120.1 |
42.9/110.1 |
38.0/89.5 |
14.2/105.3 |
||||||
22 |
Mother | +/+ | 30 |
30 |
|||||||
Infant |
22.8/116.5 |
11.8/104.4 |
8.7/99.8 |
1.9/75.2 |
|||||||
23 |
Mother | +/+ | 10.5/101.6 | 4.3/115.6 | 32+1 |
32+1 |
|||||
Infant |
15.8/222.1 |
33.8/182.5 |
9.0/88.2 |
6.1/82.5 |
0.5/31.1 |
||||||
24 | Mother | +/+ | –/+ | 8.0/83.9 | NA | NA | |||||
Infant | 30.1/106.0 | 29.5/84.6 | 31.5/94.9 | 9.7/73.1 |
*Bold text indicates titer >10 AU/mL (i.e., above cutoff). GA, gestational age; NA, not available; –, negative; +, positive.
†Some mothers delivered in other hospitals, and antibody testing was conducted using other qualitative antibody-detection kits.
1These first authors contributed equally to this article.