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Volume 26, Number 11—November 2020

Azithromycin to Prevent Pertussis in Household Contacts, Catalonia and Navarre, Spain, 2012–2013

Josep Alvarez, Pere GodoyComments to Author , Pedro Plans-Rubio, Neus Camps, Monica Carol, Gloria Carmona, Ruben Solano, Cristina Rius, Sofia Minguell, Irene Barrabeig, Maria R. Sala-Farré, Raquel Rodriguez, Manuel Garcia-Cenoz, Carmen Muñoz-Almagro, Angela Dominguez, and Transmission of Pertussis in Households Working Group1
Author affiliations: Agència de Salut Pública de Catalunya, Barcelona, Spain (J. Alvarez, P. Godoy, P. Plans-Rubio, N. Camps, M. Carol, G. Carmona, S. Minguell, I. Barrabeig, M.R. Sala-Farré, R. Rodriguez); Institut de Recerca Biomédica de Lleida, Leida, Spain (P. Godoy); Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERSP), Madrid, Spain (P. Godoy, P. Plans-Rubio, R. Solano, C. Rius, I. Barrabeig, M. García Cenoz, C. Muñoz-Almagro, A. Domínguez); Agència de Salut Pública de Barcelona, Barcelona (R. Solano, C. Rius); Instituto de Salud Pública de Navarra, Pamplona, Spain (M. Garcia-Cenoz); Hospital de Sant Joan de Deu, Barcelona (C. Muñoz-Almagro); Universitat de Barcelona, Barcelona (A. Dominguez)

Main Article

Table 2

Effectiveness of chemoprophylaxis to prevent pertussis transmission among 1,975 household contacts, Catalonia and Navarre, Spain, 2012–2013

Chemoprophylaxis timing for contacts* No. contacts Type of contact
Effectiveness, % (95% CI)
Healthy contact, no. (%) Secondary case-patient, no. (%)
All 1,914 1831 (95.7) 64 (3.3)
1–21 d 1,266 1,227 (96.9) 39 (3.1) 43.9 (−1.8 to 69.1)
>21 d 393 363 (92.4) 30 (7.6) −39.0 (−157.0 to 25.0)
No chemoprophylaxis
241 (94.5)
14 (5.5)
Completely vaccinated
1–21 d 248 233 (94.0) 15 (6.0) 44.1 (−59.5 to 80.4)
No chemoprophylaxis
33 (89.2)
4 (10.8)
Incompletely vaccinated
1–21 d 50 45 (90.0) 5 (10.0) 50.0 (−248.0, 92.8)
No chemoprophylaxis 5 4 (80.0) 1 (20.0) Reference

*No. days after symptom onset in primary patient whose contacts received chemoprophylaxis. Includes vaccination status of contacts <18 years of age.

Main Article

1Members of the Transmission of Pertussis in Households Working Group who contributed data are listed at the end of this article.

Page created: August 28, 2020
Page updated: October 17, 2020 10:08 PM EDT
Page reviewed: October 17, 2020 10:08 PM EDT
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