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Volume 26, Number 11—November 2020
Research

Azithromycin to Prevent Pertussis in Household Contacts, Catalonia and Navarre, Spain, 2012–2013

Josep Alvarez, Pere GodoyComments to Author , Pedro Plans-Rubio, Neus Camps, Monica Carol, Gloria Carmona, Ruben Solano, Cristina Rius, Sofia Minguell, Irene Barrabeig, Maria R. Sala-Farré, Raquel Rodriguez, Manuel Garcia-Cenoz, Carmen Muñoz-Almagro, Angela Dominguez, and Transmission of Pertussis in Households Working Group1
Author affiliations: Agència de Salut Pública de Catalunya, Barcelona, Spain (J. Alvarez, P. Godoy, P. Plans-Rubio, N. Camps, M. Carol, G. Carmona, S. Minguell, I. Barrabeig, M.R. Sala-Farré, R. Rodriguez); Institut de Recerca Biomédica de Lleida, Leida, Spain (P. Godoy); Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERSP), Madrid, Spain (P. Godoy, P. Plans-Rubio, R. Solano, C. Rius, I. Barrabeig, M. García Cenoz, C. Muñoz-Almagro, A. Domínguez); Agència de Salut Pública de Barcelona, Barcelona (R. Solano, C. Rius); Instituto de Salud Pública de Navarra, Pamplona, Spain (M. Garcia-Cenoz); Hospital de Sant Joan de Deu, Barcelona (C. Muñoz-Almagro); Universitat de Barcelona, Barcelona (A. Dominguez)

Main Article

Table 1

Characteristics of household contacts of primary patients with pertussis, Catalonia and Navarre, Spain, 2012–2013

Characteristic Contacts* Received chemoprophylaxis*
p value†
Yes No
Total
1,975 (100)
1,720 (87.1)
255 (12.9)

Sex
M 919 (46.5) 797 (46.3) 122 (47.8) 0.64
F
1,056 (53.5)
923 (53.7)
133 (52.2)

Age, y
<1 44 (2.2) 41 (2.4) 3 (1.2) 0.67
1 33 (1.7) 33 (1.9) 0 (0.0)
2–3 79 (4.0) 67 (3.9) 12 (4.7)
4–6 132 (6.7) 120 (7.0) 12 (4.7)
7–10 154 (7.8) 135 (7.8) 19 (7.5)
11–18 149 (7.5) 131 (7.6) 18 (7.1)
19–40 685 (34.7) 595 (34.6) 90 (35.3)
>40 699 (35.4) 598 (34.8) 101 (39.6)
Mean age, y (± SD) 33.9 (20.5) 33.4 (20.5) 37.3 (20.6) 0.005‡
Median age, y
36
36
39

Type of household contact
Household cohabitant 1,511 (76.5) 1,311 (76.2) 200 (78.4) 0.44
Other >2 h
464 (23.5)
409 (23.8)
55 (21.6)

Relationship to primary patient
Mother 463 (23.4) 400 (23.3) 63 (24.7) 0.69
Father 424 (21.5) 366 (21.3) 58 (22.7)
Sibling 388 (19.6) 352 (20.5) 36 (14.1)
Grandparent 281 (14.2) 248 (14.4) 33 (12.9)
Child 19 (1.0) 15 (0.9) 4 (1.6)
Spouse 26 (1.3) 20 (1.2) 6 (2.4)
Other
374 (18.9)
319 (18.5)
55 (21.6)

Vaccination status <18 y 591 527 64
Fully vaccinated (>4 doses) 388 (65.7) 349 (66.2) 39 (60.9) 0.36
Incomplete for age 36 (6.1) 35 (6.6) 1 (1.6)
Incomplete 16 (2.7) 15 (2.8) 1 (1.6)
Not vaccinated 24 (4.1) 21 (4.0) 3 (4.7)
Too young for vaccination 5 (0.8) 4 (0.8) 1 (1.6)
Not stated
122 (20.6)
103 (19.5)
19 (29.7)

Chemoprophylaxis initiation, d§
1–7 309 (15.6) 309 (18.0) 0
8–14 544 (27.5) 544 (31.6) 0
15–21 413 (20.9) 413 (24.0) 0
>21 393 (19.9) 393 (22.8) 0
Unknown 61 (3.1) 61 (3.5) 0
No chemoprophylaxis
255 (12.9)
255 (14.8)
0

Type of contact
Healthy contact 1,886 (95.5) 1,645 (95.6) 241 (94.5) 0.44
Secondary case 89 (4.5) 75 (4.4) 14 (5.5)

*Values are no. (%) except as indicated.
†p value for χ2 test.
‡p value for Student t-test.
§Days after symptom onset of the primary patient.

Main Article

1Members of the Transmission of Pertussis in Households Working Group who contributed data are listed at the end of this article.

Page created: August 28, 2020
Page updated: October 17, 2020 10:08 PM EDT
Page reviewed: October 17, 2020 10:08 PM EDT
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