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Volume 26, Number 11—November 2020

Azithromycin to Prevent Pertussis in Household Contacts, Catalonia and Navarre, Spain, 2012–2013

Josep Alvarez, Pere GodoyComments to Author , Pedro Plans-Rubio, Neus Camps, Monica Carol, Gloria Carmona, Ruben Solano, Cristina Rius, Sofia Minguell, Irene Barrabeig, Maria R. Sala-Farré, Raquel Rodriguez, Manuel Garcia-Cenoz, Carmen Muñoz-Almagro, Angela Dominguez, and Transmission of Pertussis in Households Working Group1
Author affiliations: Agència de Salut Pública de Catalunya, Barcelona, Spain (J. Alvarez, P. Godoy, P. Plans-Rubio, N. Camps, M. Carol, G. Carmona, S. Minguell, I. Barrabeig, M.R. Sala-Farré, R. Rodriguez); Institut de Recerca Biomédica de Lleida, Leida, Spain (P. Godoy); Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERSP), Madrid, Spain (P. Godoy, P. Plans-Rubio, R. Solano, C. Rius, I. Barrabeig, M. García Cenoz, C. Muñoz-Almagro, A. Domínguez); Agència de Salut Pública de Barcelona, Barcelona (R. Solano, C. Rius); Instituto de Salud Pública de Navarra, Pamplona, Spain (M. Garcia-Cenoz); Hospital de Sant Joan de Deu, Barcelona (C. Muñoz-Almagro); Universitat de Barcelona, Barcelona (A. Dominguez)

Main Article

Table 3

Effect of delay in chemoprophylaxis on preventing pertussis transmission among 1,975 household contacts, Catalonia and Navarre, Spain, 2012–2013

Chemoprophylaxis for contacts, d* No. contacts Type of contact
Effectiveness, % (95% CI) Adjusted effectiveness, %† (95% CI)
Healthy contact, no. (%) Secondary case-patient, no. (%)
1–7 309 306 (99.0) 3 (1.0) 82.3 (39.1, 94.9) 89.0 (6.7, 98.7)
8–14 544 528 (97.1) 16 (2.9) 46.4 (−8.1 to 73.4) 37.2 (−114.9 to 75.4)
15–21 413 393 (95.2) 20 (4.8) 11.8 (−71.5 to 54.6) 2.8 (−171.3 to 65.2)
No chemoprophylaxis 255 241 (94.5) 14 (5.5) Referent

*No. days after symptom onset in primary patient whose contacts received chemoprophylaxis.
†Adjusted by vaccination status.

Main Article

1Members of the Transmission of Pertussis in Households Working Group who contributed data are listed at the end of this article.

Page created: August 28, 2020
Page updated: October 17, 2020 10:08 PM EDT
Page reviewed: October 17, 2020 10:08 PM EDT
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