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Volume 26, Number 11—November 2020
Research

High Dengue Burden and Circulation of 4 Virus Serotypes among Children with Undifferentiated Fever, Kenya, 2014–2017

Melisa M. ShahComments to Author , Bryson A. Ndenga, Francis M. Mutuku, David M. Vu, Elysse N. Grossi-Soyster, Victoria Okuta, Charles O. Ronga, Philip K. Chebii, Priscilla Maina, Zainab Jembe, Carren M. Bosire, Jael S. Amugongo, Malaya K. Sahoo, ChunHong Huang, Jenna Weber, Sean V. Edgerton, Jimmy Hortion, Shannon N. Bennett, Benjamin A. Pinsky, and A. Desiree LaBeaud
Author affiliations: Stanford University School of Medicine, Stanford, California, USA (M.M. Shah, D.M. Vu, E.N. Grossi-Soyster, M.K. Sahoo, C. Huang, J. Weber, J. Hortion, B.A. Pinsky, A.D. LaBeaud); Kenya Medical Research Institute, Kisumu, Kenya (B.A. Ndenga, V. Okuta, C.O. Ronga); Technical University of Mombasa, Mombasa, Kenya (F.M. Mutuku, C.M. Bosire, J.S. Amugongo); Msambweni County Referral Hospital, Msambweni, Kenya (P.K. Chebii, P. Maina); Diani Health Center, Ukunda, Kenya (Z. Jembe); California Academy of Sciences, San Francisco, California, USA (S.V. Edgerton, S.N. Bennett); École Normale Supérieure de Lyon, Lyon, France (J. Hortion)

Main Article

Table 1

Characteristics of participants by geographic location in study of dengue burden and circulation of 4 virus serotypes among children with undifferentiated fever, Kenya, 2014–2017*

Characteristic Coastal clinics (Msambweni and Ukunda), n = 422 Western clinics (Chulaimbo and Kisumu), n = 600 p value
Mean (SD) age, y
 6.7 (4.4)
 4.6 (2.9)
 <0.001
Sex
F 188 (44.5) 279 (46.5) 0.58
M
 234 (55.5)
 321 (53.5)
 0.58
Always uses bednet 400 (94.8) 418 (69.7) <0.001
Wealth index <3† 272 (64.5) 329 (54.8) 0.003
Mean (SD) no. illness days before seeking care 2.3 (0.72) 3.1 (1.9) <0.001
Dengue viremic by rRT-PCR 106 (34.2) 255 (46.2) 0.001
DENV IgG present at febrile visit 19 (4.5) 7 (1.2) 0.003
Malaria smear positive 194 (47.1) 247 (56.8) 0.006

*Values are no. (%) unless indicated otherwise. DENV, dengue virus; rRT-PCR, real-time reverse transcription PCR.
†Defined as a household having <3 of the following: domestic worker, bicycle, telephone, radio, motor vehicle, and television.

Main Article

Page created: August 06, 2020
Page updated: October 17, 2020
Page reviewed: October 17, 2020
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