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Volume 26, Number 11—November 2020
Research

High Dengue Burden and Circulation of 4 Virus Serotypes among Children with Undifferentiated Fever, Kenya, 2014–2017

Melisa M. ShahComments to Author , Bryson A. Ndenga, Francis M. Mutuku, David M. Vu, Elysse N. Grossi-Soyster, Victoria Okuta, Charles O. Ronga, Philip K. Chebii, Priscilla Maina, Zainab Jembe, Carren M. Bosire, Jael S. Amugongo, Malaya K. Sahoo, ChunHong Huang, Jenna Weber, Sean V. Edgerton, Jimmy Hortion, Shannon N. Bennett, Benjamin A. Pinsky, and A. Desiree LaBeaud
Author affiliations: Stanford University School of Medicine, Stanford, California, USA (M.M. Shah, D.M. Vu, E.N. Grossi-Soyster, M.K. Sahoo, C. Huang, J. Weber, J. Hortion, B.A. Pinsky, A.D. LaBeaud); Kenya Medical Research Institute, Kisumu, Kenya (B.A. Ndenga, V. Okuta, C.O. Ronga); Technical University of Mombasa, Mombasa, Kenya (F.M. Mutuku, C.M. Bosire, J.S. Amugongo); Msambweni County Referral Hospital, Msambweni, Kenya (P.K. Chebii, P. Maina); Diani Health Center, Ukunda, Kenya (Z. Jembe); California Academy of Sciences, San Francisco, California, USA (S.V. Edgerton, S.N. Bennett); École Normale Supérieure de Lyon, Lyon, France (J. Hortion)

Main Article

Table 3

Characteristics of participants by DENV serotype in study of dengue burden and circulation of 4 virus serotypes among children with undifferentiated fever, Kenya, 2014–2017*

Characteristic DENV-1, n = 36 DENV-2, n = 105 DENV-3, n = 10 DENV-4, n = 11 Mixed, n = 59 p value
Mean (SD) age, y 4.4 (2.8) 5.2 (3.3) 5.8 (3.9) 3.8 (1.6) 5.6 (3.3) 0.21
Mean (SD) viral load, log10 cDNA copies/μL
6.1 (2.5)
5.7 (2.2)
9.7 (3.8)
5.2 (2.7)
7.9 (1.8)
<0.001
Site <0.001
Chulaimbo 5 (13.9) 53 (50.5) 2 (20.0) 1 (9.1) 26 (49.2)
Kisumi 10 27.8) 28 (26.7) 7 (70.0) 10 (90.9) 25 (42.4)
Msambweni 21 (58.3) 12 (11.4) 1 (10.0) 0 0
Ukunda
0
12 (11.4)
0
0
0

Mean (SD) no. illness days before seeking care 2.6 (1.6) 2.9 (1.9) 3.5 (1.5) 2.8 (1.47) 2.6 (1.3) 0.46
Malaria smear positive 18 (51.4) 42 (55.3) 3 (42.9) 4 (45.5) 23 (62.2) 0.78

*Values are no. (%) unless indicated otherwise. cDNA, complementary DNA; DENV, dengue virus.

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Page created: August 06, 2020
Page updated: October 17, 2020 10:18 PM EDT
Page reviewed: October 17, 2020 10:18 PM EDT
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