Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 26, Number 11—November 2020
CME ACTIVITY - Research

Phage-Mediated Immune Evasion and Transmission of Livestock-Associated Methicillin-Resistant Staphylococcus aureus in Humans

Raphael N. Sieber, Tinna R. Urth, Andreas Petersen, Camilla H. Møller, Lance B. Price, Robert L. Skov, Anders R. Larsen, Marc Stegger1, and Jesper Larsen1Comments to Author 
Author affiliations: Statens Serum Institut, Copenhagen, Denmark (R.N. Sieber, T.R. Urth, A. Petersen, C.H. Møller, R.L. Skov, A.R. Larsen, M. Stegger, J. Larsen); Translational Genomics Research Institute, Flagstaff, Arizona, USA (L.B. Price, M. Stegger); George Washington University, Washington, DC, USA (L.B. Price)

Main Article

Table 1

Distribution of IEC-harboring ΦSa3int prophages among livestock-associated methicillin-resistant Staphylococcus aureus CC398 isolates from North Denmark Region, Denmark*

Variant Phylogenetic cluster† IEC type Integration site‡ tarP Isolate origin Household ID Farm ID
I A B 0723–0724 – 1 pig farm employee and 4 household members H02 F01
II B E 2238 – 1 pig farm employee and 1 household member H30 F01
III C B 2059 (hlb) – 1 pig farm employee and 3 household members H63 F04
IV D B 2591 (cidA) – 1 pig farm employee H51 F07
V E F 2059 (hlb) + 1 pig veterinarian H46 None
VI E F 2644 + 1 mink farm employee and 3 household members H49 F21
E F 2644 + Pig NA A
E F 2644 + Pig NA B
E F 2644 + Pig NA C

*Allocation of ΦSa3int prophages into variants (ΦSa3int-I to ΦSa3int-VI) was based on their phylogenetic relationship, IEC type, and chromosomal integration site. CC, clonal complex; ID, identification; IEC, immune evasion cluster; NA, not applicable; –, negative, +, positive. 
†Phylogenetic clusters are illustrated in Figure 1.
‡Numbers refer to annotated genes in reference strain S0385 (GenBank accession no. NC_017333).

Main Article

1These senior authors contributed equally to this article.

Page created: September 11, 2020
Page updated: October 15, 2020
Page reviewed: October 15, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external